SML0142

Valsartan

≥98% (HPLC)

• Synonym(e): N-(1-Oxopentyl)-N-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]-methyl]-L-valin
• Empirische Formel (Hill-System): C₂₄H₂₉N₅O₃
• CAS-Nummer: 137862-53-4
• Molekulargewicht: 435.52
• MDL-Nummer: MFCD00865840
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825190
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D -55 to -70°, c = 1 in methanol
• Lagerbedingungen: desiccated
• Farbe: white to tan
• Löslichkeit: DMSO: ≥20 mg/mL
• Ersteller: Novartis
• Lagertemp.: 2-8°C
• SMILES String: CCCCC(=O)N(Cc1ccc(cc1)-c2ccccc2-c3nnn[nH]3)[C@@H](C(C)C)C(O)=O
• InChI: 1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1
• InChIKey: ACWBQPMHZXGDFX-QFIPXVFZSA-N
• Angaben zum Gen: human ... AGTR1(185)

Beschreibung

Anwendung

Mice were treated with valsartan to study the role of Ang II-dependent pathway in aldosterone-related effects.

Biochem./physiol. Wirkung

Valsartan is an Angiotensin II type 1 (AT1) receptor antagonist and anti-hypertensive. Valsartan renders protection against heart attack and stroke resulting from abrupt increase in blood pressure. Valsartan reduces myocardial-infarction-related complications in heart attack survivors.

Leistungsmerkmale und Vorteile

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Warning
• H-Sätze: H336,H361d
• P-Sätze: P201 - P308 + P313
• Gefahreneinstufungen: Repr. 2 - STOT SE 3
• Zielorgane: Central nervous system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable