SMB00387

Prothionamide

≥99% (HPLC)

• Synonym(e): Prothionamide, 2-propyl-4-pyridinecarbothioamide, 2-propylisonicotinylthioamide, 2-propylthioisonicotinamide, 2-Propyl-4-pyridinecarbothioamide, 2-Propylisonicotinylthioamide
• Empirische Formel (Hill-System): C₉H₁₂N₂S
• CAS-Nummer: 14222-60-7
• Molekulargewicht: 180.27
• MDL-Nummer: MFCD00464119
• UNSPSC-Code: 51101500
• PubChem Substanz-ID: 329824982
• NACRES: NA.85

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥99% (HPLC)
• Form: powder
• Lagerbedingungen: (Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Non Combustible liquids.)
• Farbe: yellow
• Wirkungsspektrum von Antibiotika: mycobacteria
• Wirkungsweise: enzyme | interferes
• Lagertemp.: −20°C
• SMILES String: NC(C1=CC(CCC)=NC=C1)=S
• InChI: 1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)
• InChIKey: VRDIULHPQTYCLN-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Chemical structure: pyridine

Prothionamide is an analogue of ethionamide, and is better tolerated and less toxic than ethionamide. It contains a propyl group instead of an ethyl group at the α position.

Biochem./physiol. Wirkung

Prothionamide is the second line of drug used in leprosy and in tuberculosis. It is highly effective against Mycobacterium tuberculosis. In patients with multidrug-resistant tuberculosis (MDR-TB), prothionamide causes the development of hepatitis. In rare cases, it causes drug reaction with eosinophilia and systemic symptoms (DRESS) in patients with MDR-TB. DRESS is characterized by fever, hematologic abnormalities, skin eruption, and internal organ disruption.

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable