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Key Documents

SCP0168

Sigma-Aldrich

Histone Deacetylase Substrate

≥95% (HPLC), lyophilized

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About This Item

Empirische Formel (Hill-System):
C23H31N3O6
Molekulargewicht:
445.51
UNSPSC-Code:
12352204
NACRES:
NA.32

product name

Histone Deacetylase Substrate,

Assay

≥95% (HPLC)

Form

lyophilized

Zusammensetzung

Peptide Content, ≥85%

Lagerbedingungen

protect from light

Lagertemp.

−20°C

Amino Acid Sequence

BOC-Ac-Lys-AMC

Anwendung

BOC-Ac-Lys-AMC (MAL) is used as a fluorogenic substrate for assaying both human zinc and NAD+-dependent histone deacetylases.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Birgit Heltweg et al.
Methods (San Diego, Calif.), 36(4), 332-337 (2005-08-10)
Histone deacetylases are important regulators of transcription and an emerging target for anticancer drugs. We present an overview over various assay formats that include radiolabelled histones, oligopeptides, and small molecules as substrates. The advantages and disadvantages of the various formats
Birgit Heltweg et al.
Analytical biochemistry, 319(1), 42-48 (2003-07-05)
Histone deacetylases (HDACs) are involved in the regulation of transcription and their inhibitors are a promising class of new anticancer drugs. We have previously reported Boc(Ac)Lys-AMC, also termed MAL, as a fluorescent substrate for HDACs. Now we present a modification
Neetinkumar D Reddy et al.
Chemico-biological interactions, 233, 81-94 (2015-04-01)
The potential of cinnamic acid as an anti-inflammatory and anti-cancer agent has been studied previously. In our investigation, novel bio-isosters of cinnamyl sulfonamide hydroxamate were synthesized, characterized and confirmed for their structure and evaluated for cytotoxicity. Three NCEs namely, NMJ-1

Artikel

Histone Modification and Chromatin Remodeling | Epigenetics

Epigenetic modifications are thought to occur through two key interconnected processes—DNA methylation and the covalent modification of histones.

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