SBNMQ

NMQ/N-methyl-quinidine - MDR1/P-gp Substrate

• Synonym(e): SB-NMQ, N-methyl-quinidine (NMQ), NMQ
• Empirische Formel (Hill-System): C₂₁H₂₇IN₂O₂
• CAS-Nummer: 42982-87-6
• Molekulargewicht: 466.36
• UNSPSC-Code: 12352200
• NACRES: NA.84

Eigenschaften

• Form: powder
• Farbe: white
• Lagertemp.: room temp
• SMILES String: [I-].[N+]21([C@H](CC([C@H](C2)C=C)CC1)[C@@H](O)c3c4c(ncc3)ccc(c4)OC)C
• InChI: 1S/C21H27N2O2.HI/c1-4-14-13-23(2)10-8-15(14)11-20(23)21(24)17-7-9-22-19-6-5-16(25-3)12-18(17)19;/h4-7,9,12,14-15,20-21,24H,1,8,10-11,13H2,2-3H3;1H/q+1;/p-1/t14-,15?,20+,21-,23?;/m0./s1
• InChIKey: AJQSDVGBERUTGX-QVEQJUGRSA-M

Beschreibung

Anwendung

NMQ/N-methyl-quinidine - MDR1/P-gp substrate has been used as a probe substrate for multidrug resistance protein 1 (MDR1) in vesicles assay.

Biochem./physiol. Wirkung

SOLVO Biotechnology offers NMQ as a selective substrate for the MDR1 membrane transporter.

NMQ was shown to be actively transported by human MDR1/P-gp and rat Mdr1b efflux transporters.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable