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Key Documents

SAB5300353

Monoclonal Anti-CASP8 antibody produced in mouse

Name: Monoclonal Anti-CASP8 antibody produced in mouse
Brand: SIGMA

clone 1H11, ascites fluid

Synonym(e):

ALPS2B, CAP4, FLICE, MACH, MCH5

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About This Item

UNSPSC-Code:

12352203

NACRES:

NA.41

Biologische Quelle

mouse

Konjugat

unconjugated

Antikörperform

ascites fluid

Antikörper-Produkttyp

primary antibodies

Klon

1H11, monoclonal

Mol-Gew.

26 kDa

Speziesreaktivität

human, mouse, rat, monkey

Methode(n)

direct ELISA: 1:10,000
flow cytometry: 1:200-1:400
immunohistochemistry: 1:200-1:1,000
western blot: 1:500-1:2,000

Isotyp

IgG1

NCBI-Hinterlegungsnummer

NM_001080124

UniProt-Hinterlegungsnummer

Q14790

Versandbedingung

wet ice

Lagertemp.

−20°C

Angaben zum Gen

human ... CASP8(841)

Immunogen

Purified recombinant fragment of human CASP8 expressed in E.coli.
Mouse monoclonal antibody raised against CASP8

Physikalische Form

Ascitic fluid containing 0.03% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Chemosensitization of rhabdomyosarcoma cells by the histone deacetylase inhibitor SAHA.

Ulrike Heinicke et al.

Cancer letters, 351(1), 50-58 (2014-05-13)

Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in childhood with a dismal prognosis, highlighting the need for novel treatment strategies. Here, we identify a novel synthetic lethal interaction between the histone deacetylase inhibitor (HDACI) SAHA and anticancer drugs in

Ultrasound-targeted microbubble destruction combined with dual targeting of HSP72 and HSC70 inhibits HSP90 function and induces extensive tumor-speciﬁc apoptosis.

Hanghui Wang et al.

International journal of oncology, 45(1), 157-164 (2014-04-17)

The specific and efficient delivery of small interfering RNA (siRNA) into cancer cells in vivo remains a major obstacle. In this study, we investigated whether ultrasound-targeted microbubble destruction (UTMD) combined with dual targeting of HSP72 and HSC70 in prostate cancer cell

Mitochondria autophagy is induced after hypoxic/ischemic stress in a Drp1 dependent manner: the role of inhibition of Drp1 in ischemic brain damage.

Wei Zuo et al.

Neuropharmacology, 86, 103-115 (2014-07-16)

Mitochondria dysfunction is implicated in diverse conditions, including metabolic and neurodegenerative disorders. Mitochondrial dynamics has attracted increasing attention as to its relationship with mitochondria autophagy, also known as mitophagy, which is critical for degradation of dysfunctional mitochondria maintaining mitochondrial homeostasis.

Caspase-8 mutations in head and neck cancer confer resistance to death receptor-mediated apoptosis and enhance migration, invasion, and tumor growth.

Changyou Li et al.

Molecular oncology, 8(7), 1220-1230 (2014-05-13)

Little is known regarding molecular markers in head and neck squamous cell carcinoma (HNSCC) that predict responsiveness to different therapeutic regimens or predict HNSCC progression. Mutations in procaspase-8 occur in 9% of HNSCC primary tumors, but the functional consequences of

Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening.

Sireesha V Garimella et al.

Breast cancer research : BCR, 16(2), R41-R41 (2014-04-22)

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) binds to its receptors, TRAIL-receptor 1 (TRAIL-R1) and TRAIL-receptor 2 (TRAIL-R2), leading to apoptosis by activation of caspase-8 and the downstream executioner caspases, caspase-3 and caspase-7 (caspase-3/7). Triple-negative breast cancer (TNBC) cell lines with

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