SAB4502581

Anti-Retinoic Acid Receptor β, C-Terminal antibody produced in rabbit

affinity isolated antibody

• Synonym(e): HBV-activated protein, RAR-β, RAR-ε, nuclear receptor 1B2, retinoic acid receptor β
• MDL-Nummer: MFCD00802879
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen 50 kDa
• Speziesreaktivität: mouse, human
• Konzentration: ~1 mg/mL
• Methode(n): ELISA: 1:20000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI-Hinterlegungsnummer: P10826
• UniProt-Hinterlegungsnummer: P10826
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... RARB(5915)

Beschreibung

Allgemeine Beschreibung

Anti-Retinoic Acid Receptor β Antibody detects endogenous levels of total Retinoic Acid Receptor β protein.

Retinoic Acid Receptor β (RARB) is encoded by the gene mapped to human chromosome 3p24.2-p25. The encoded protein belongs to the nuclear receptor superfamily.

Immunogen

The antiserum was produced against synthesized peptide derived from human Retinoic Acid Receptor beta.

Immunogen Range: 331-380

Biochem./physiol. Wirkung

Retinoic Acid Receptor β (RARB) interacts with its ligand retinoic acid (RA) and retinoid and plays a vital role in normal lung development. It is also involved in growth regulation of mammary epithelial cells. RARB acts as a tumor suppressor protein in various types of cancers, including thyroid carcinomas.
Mutation in the gene is associated with the development of anophthalmia and/or microphthalmia and diaphragmatic hernia. RARβ gene inactivation caused by RARβ methylation contributes to the pathogenesis of non-small cell lung cancer (NSCLC) and acts as a potential biomarker, risk factor and therapeutic target for NSLC.

Leistungsmerkmale und Vorteile

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Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable