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Merck

SAB4502580

Sigma-Aldrich

Anti-Retinoic Acid Receptor α antibody produced in rabbit

affinity isolated antibody

Synonym(e):

NR1B1, Nuclear receptor subfamily 1 group B member 1, RAR-α, RARA, Retinoic acid receptor α

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About This Item

MDL-Nummer:
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 50 kDa

Speziesreaktivität

human, mouse, rat

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:10000
western blot: 1:500-1:1000

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... RARA(5914)

Allgemeine Beschreibung

Anti-Retinoic Acid Receptor α Antibody detects endogenous levels of total Retinoic Acid Receptor α protein.
Retinoic acid receptor α (RARα) is a nuclear receptor for retinoic acid and is expressed in the retina. It belongs to the nuclear steroid/thyroid hormone receptor superfamily. The gene encoding it is localized on human chromosome 17q21.

Immunogen

The antiserum was produced against synthesized peptide derived from human Retinoic Acid Receptor alpha.

Immunogen Range: 46-95

Biochem./physiol. Wirkung

Retinoic acid receptor α (RARα) is a ligand-dependent transcriptional modulator of genes that has a role in differentiation, cellular development and apoptosis. It has a role in germ-cell development in testis. The protein may be associated with acute promyelocytic leukemia.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Enhanced expression of retinoic acid receptor alpha (RARA) induces epithelial-to-mesenchymal transition and disruption of mammary acinar structures.
Doi A
Molecular Oncology, 9(2), 355-364 (2015)
Activity of retinoic acid receptor-alpha is directly regulated at its protein kinase A sites in response to follicle-stimulating hormone signaling.
Santos NC and Kim KH
Endocrinology, 151(5), 2361-2372 (2010)
The retinoic acid receptor alpha (RARA) gene is not associated with myopia, hypermetropia, and ocular biometric measures.
Veerappan S
Molecular Vision, 15, 1390-1397 (2009)
NLS-RARa promotes proliferation and inhibits differentiation in HL-60 cells.
Hu XX
International Journal of Medical Sciences, 11(3), 247-254 (2014)
Kohichi Kawahara et al.
Journal of Alzheimer's disease : JAD, 42(2), 587-605 (2014-06-12)
Alzheimer's disease (AD) is a neurodegenerative process involving amyloid-β (Aβ) peptide deposition, neuroinflammation, and progressive memory loss. Here, we evaluated whether oral administration of retinoic acid receptor (RAR)α,β agonist Am80 (tamibarotene) or specific retinoid X receptor (RXR) pan agonist HX630

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

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