SAB4301075

Anti-DGAT1 antibody produced in rabbit

affinity isolated antibody

• Synonym(e): ARAT, ARGP1, DGAT
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: 55 kDa
• Speziesreaktivität: rat, mouse, human
• Konzentration: 2.8 mg/mL
• Methode(n): immunohistochemistry: 1:50- 1:200; western blot: 1:500-1:2000 (Cell Lysate)
• Isotyp: IgG
• Hinterlegungsnummer: NP_036211.2
• UniProt-Hinterlegungsnummer: O75907
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... DGAT1(8694)

Beschreibung

Allgemeine Beschreibung

Diacylglycerol-acyltransferase 1 (DGAT1), a transmembrane protein, is a member of the membrane-bound O-acyltransferase superfamily. It is seen in the endoplasmic reticulum of several cells. DGAT1 is ubiquitously expressed in humans. A high level of mRNA is seen in the small intestine. It has three transmembrane domains. The DGAT1 gene is mapped to human chromosome 8q24.3.

Spezifität

The antibody detects endogenous levels of total DGAT1 protein.

Immunogen

Synthetic peptide corresponding to a region derived from internal residues of human diacylglycerol O-acyltransferase 1

Anwendung

Anti-DGAT1 antibody produced in rabbit has been used in immunoblotting.

Biochem./physiol. Wirkung

Diacylglycerol-acyltransferase 1 (DGAT1) converts diacylglycerol and fatty acyl-CoA to triacylglycerol. It participates in energy storage. DGAT1 plays a key role in cancer progression. Activity of DGAT1 is essential for the physiologic absorption of vitamin D. Absence of DGAT1 activity is linked with body weight and adiposity reduction, and increased insulin sensitivity. Aberrations in the DGAT1 gene are associated with congenital diarrheal disorder (CDD).

Leistungsmerkmale und Vorteile

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Physikalische Form

Rabbit IgG in pH7.3 PBS, 0.05% NaN₃, 50% Glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable