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Merck

SAB3500598

Sigma-Aldrich

Anti-ZIP8 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(e):

Anti-BIGM103, Anti-PP3105, Anti-SLC39A8, Anti-Slc39A8, Anti-Solute carrier family 39 member A8

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Speziesreaktivität

human

Methode(n)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... SLC39A8(64116)

Allgemeine Beschreibung

Solute carrier family 39 member 8 (SLC39A8), also known as zinc- and iron-related protein 8 (ZIP8), is a plasma membrane transporter protein. It is part of the solute carrier gene superfamily. The gene encoding SLC39A8 is localized on human chromosome 4q24.

Immunogen

ZIP8 antibody was raised against a 18 amino acid peptide near the carboxy terminus of human ZIP8.

Anwendung

Anti-ZIP8 antibody produced in rabbit has been used in immunocytochemistry.

Biochem./physiol. Wirkung

Solute carrier family 39 member 8 (SLC39A8) co-transports divalent metal cations like cadmium, zinc, manganese and iron. It has a crucial role in the cellular uptake of cadmium. The protein is a target of nuclear-factor κB (NF-κB) and has a role in pro-inflammatory responses.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Verlinkung

The action of this antibody can be blocked using blocking peptide SBP3500598.

Physikalische Form

Supplied in PBS with 0.02% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Autosomal-Recessive Intellectual Disability with Cerebellar Atrophy Syndrome Caused by Mutation of the Manganese and Zinc Transporter Gene SLC39A8.
Boycott KM
American Journal of Human Genetics (2015)
ZIP8 regulates host defense through zinc-mediated inhibition of NF-?B.
Liu MJ
Cell Reports (2013)
A blood pressure-associated variant of the SLC39A8 gene influences cellular cadmium accumulation and toxicity.
Zhang R
Human Molecular Genetics (2016)
Advances in the genetics of schizophrenia: toward a network and pathway view for drug discovery: Advances in the genetics of schizophrenia
David A
The New York State Dental Journal (2016)
Cellular localization and developmental
changes of Zip8, Zip14 and transferrin
receptor 1 in the inner ear of rats
Dalian Ding
Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, And Medicine (2014)

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