SAB1300464

Anti-WNK1 (C-term) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Synonym(e): Anti-Lysine deficient 1, Anti-PRKWNK1, Anti-Protein kinase
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: IgG fraction of antiserum
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Speziesreaktivität: human
• Methode(n): immunohistochemistry: 1:50-1:100; indirect ELISA: 1:1000
• NCBI-Hinterlegungsnummer: NP_061852
• UniProt-Hinterlegungsnummer: Q9H4A3
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... WNK1(65125)

Beschreibung

Allgemeine Beschreibung

The WNK1 gene encodes a cytoplasmic serine-threonine kinase expressed in distal nephron.[supplied by OMIM]

WNK1 (WNK lysine deficient protein kinase 1) gene is mapped to human chromosome 12p13.33. The gene is ubiquitously expressed. The encoded protein contain an active PY motif of short linear proline sequence.

Immunogen

WNK1 (Q9H4A3, 2266-2302)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human WNK1.

Biochem./physiol. Wirkung

WNK is known to influence the activity of chloride transporters such as members of the SLC12 family. WNK1 regulates ion transportation in kidney and maintains chloride concentration in the neurons. It maintains cell volume during the change in the solute concentration. Osmotic stress and chloride depletion within the cell upregulates WNK1 (WNK lysine deficient protein kinase 1) expression. Mutations in WNK1 leads to familial hyperkalemic hypertension, a Mendelian disorder characterized with thiazide-sensitive hypertension, hyperkalemia, and normal glomerular filtration rate. It is associated with hereditary syndromes like renal disease pseudohypoaldosteronism type II (PHAII) and the neurological disease hereditary sensory neuropathy 2.

Physikalische Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable