SAB4503840

Anti-phospho-WNK1 (pThr⁵⁸) antibody produced in rabbit

affinity isolated antibody

• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen 250 kDa
• Speziesreaktivität: rat, human, mouse
• Konzentration: ~1 mg/mL
• Methode(n): ELISA: 1:5000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI-Hinterlegungsnummer: Q9H4A3
• UniProt-Hinterlegungsnummer: Q9H4A3
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: phosphorylation (pThr58)
• Angaben zum Gen: human ... WNK1(65125)

Beschreibung

Allgemeine Beschreibung

The WNK1 (WNK lysine deficient protein kinase 1) gene is mapped to human chromosome 12p13.33. The encoded protein belongs to the WNK kinase family and is ubiquitously expressed.

Immunogen

The antiserum was produced against synthesized peptide derived from human WNK1 around the phosphorylation site of Thr58.

Immunogen Range: 24-73

Biochem./physiol. Wirkung

WNK1 (WNK lysine deficient protein kinase 1) is responsible for maintaining the ion homeostasis. It regulates mitogen-activated protein kinase 7 (MAPK7) mediated cell proliferation and migration. It is also known to promote tumor proliferation, invasion and metastasis in prostate carcinoma. WNK1 expression is essential for vascular remodeling and endothelial sprouting. Autophagy has been indicated in various diseases. This intracellular degradation pathway is prevented by WNK1.(3)

Leistungsmerkmale und Vorteile

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Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable