R8657

Razoxane

>98% (HPLC)

• Synonym(e): (±)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane, (±)-1,2-Bis(3,5-dioxopiperazinyl)propane, 1,2-Bis(3,5-dioxo-1-piperazinyl)propane, 4,4′-Propylenebis(2,6-piperazinedione), ICI 59118, ICRF 159, NSC 129943, Razoxin, Tepirone, Troxozone
• Empirische Formel (Hill-System): C₁₁H₁₆N₄O₄
• CAS-Nummer: 21416-67-1
• Molekulargewicht: 268.27
• EG-Nummer: 244-379-2
• MDL-Nummer: MFCD00430424
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329824039
• NACRES: NA.77

Eigenschaften

• Assay: >98% (HPLC)
• Form: solid
• Löslichkeit: DMSO: 40 mg/mL
• Lagertemp.: room temp
• SMILES String: CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
• InChI: 1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)
• InChIKey: BMKDZUISNHGIBY-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Razoxane is clinically active against angiogenesis and metastasis. Razoxane specifically inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor). It is an antimitotic agent with immunosuppressive properties. Razoxane inhibits blood-borne and lymphatic metastases in different experimental models. Studies have shown that razoxane inhibits specifically the vasculogenic mimicry of B16F10 melanoma cells.

Razoxane is clinically active against angiogenesis and metastasis; inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor).

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable