D1446

Dexrazoxan

≥95% (HPLC)

• Synonym(e): (+)-(S)-4,4′-Propylendi-2,6-piperazindion, (S)-(+)-1,2-Bis-(3,5-dioxopiperazin-1-yl)-propan
• Empirische Formel (Hill-System): C₁₁H₁₆N₄O₄
• CAS-Nummer: 24584-09-6
• Molekulargewicht: 268.27
• MDL-Nummer: MFCD00866449
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329798699
• NACRES: NA.77

Eigenschaften

• Assay: ≥95% (HPLC)
• Form: powder
• Farbe: white to off-white
• Löslichkeit: DMSO: >20 mg/mL
• Ersteller: Johnson & Johnson
• Lagertemp.: room temp
• SMILES String: C[C@@H](CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
• InChI: 1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1
• InChIKey: BMKDZUISNHGIBY-ZETCQYMHSA-N

Beschreibung

Allgemeine Beschreibung

Dexrazoxane is a member of bis(2,6-dioxopiperazines), that functions as a topoisomerase 2 catalytic inhibitor. Dexrazoxane is a free radical scavenger. It might protect the heart from doxorubicin-associated damage. Dexrazoxane acts as a cardiopulmonary protectant, while treating Hodgkin′s disease (HD). It functions as a chelating agent, which limits the formation of anthracycline-iron complexes. It is used to synthesize antimalarial drugs.

Anwendung

Dexrazoxane has been used in chromatin remodelling experiments.

Biochem./physiol. Wirkung

Dexrazoxane is a cardioprotective compound against anthracyclines. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.

Leistungsmerkmale und Vorteile

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable