R2533

RS-127445 hydrochloride

≥98% (HPLC), powder

• Synonym(e): 2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine hydrochloride
• Empirische Formel (Hill-System): C₁₇H₁₆FN₃ · HCl
• CAS-Nummer: 199864-86-3
• Molekulargewicht: 317.79
• MDL-Nummer: MFCD11112196
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329824019
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to tan
• Löslichkeit: DMSO: ≥20 mg/mL
• Ersteller: Roche
• Lagertemp.: 2-8°C
• SMILES String: Cl.CC(C)c1cc(nc(N)n1)-c2ccc(F)c3ccccc23
• InChI: 1S/C17H16FN3.ClH/c1-10(2)15-9-16(21-17(19)20-15)13-7-8-14(18)12-6-4-3-5-11(12)13;/h3-10H,1-2H3,(H2,19,20,21);1H
• InChIKey: MKJPYBJBPRFMHL-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.

Leistungsmerkmale und Vorteile

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301,H315,H319,H335
• P-Sätze: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable