R0775

RANK/Fc Chimera from mouse

≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

• Synonym(e): Osteoclast differentiation receptor, ODFR, Receptor activator of NF-κB
• MDL-Nummer: MFCD03703131
• UNSPSC-Code: 51111800
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 200
• Rekombinant: expressed in NSO cells
• Assay: ≥95% (SDS-PAGE)
• Form: lyophilized powder
• Wirksamkeit: 10.12 μg/mL EC₅₀
• Mol-Gew.: 60 kDa
• Verpackung: pkg of 1 mg
• Lagerbedingungen: avoid repeated freeze/thaw cycles
• Methode(n): cell culture | mammalian: suitable
• Verunreinigungen: endotoxin, tested
• UniProt-Hinterlegungsnummer: O35305
• Lagertemp.: −20°C
• Angaben zum Gen: mouse ... Tnfrsf11a(21934)

Beschreibung

Anwendung

RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. The biological functions mediated by RANK include activation of NF-ΚB and c-jun N-terminal kinase, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis and lymph node organogenesis.

Biochem./physiol. Wirkung

TRANCE (TNF-related activation-induced cytokines, also known as RANK ligand, osteoprotegerin ligand and osteoclast differentiation factor) is the ligand for RANK. The biological functions mediated through RANK include activation of NF-κB and c-jun N-terminal kinases, enhancement of T cell growth and dentritic cell function, induction of osteoclastogenesis, and lymph node genesis. Soluble RANK is able to block TRANCE-induced biological activity.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Hinweis zur Analyse

The biological activity is measured by its ability to inhibit TRANCE-induced osteoclast differentiation in mouse splenocytes.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable