R0283

Ropivacain -hydrochlorid Monohydrat

≥98% (HPLC)

• Synonym(e): (2S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide hydrochloride monohydrate, (S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride monohydrate, Naropin hydrochloride monohydrate
• Empirische Formel (Hill-System): C₁₇H₂₆N₂O · HCl · H₂O
• CAS-Nummer: 132112-35-7
• Molekulargewicht: 328.88
• MDL-Nummer: MFCD00946578
• UNSPSC-Code: 12352203
• PubChem Substanz-ID: 329823983
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D -9 to -12, c = 1 in methanol
• Lagerbedingungen: desiccated
• Farbe: white to off-white
• Löslichkeit: H₂O: 5 mg/mL, clear
• Ersteller: AstraZeneca
• Lagertemp.: 2-8°C
• SMILES String: O.Cl.CCCN1CCCC[C@H]1C(=O)Nc2c(C)cccc2C
• InChI: 1S/C17H26N2O.ClH.H2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H;1H2/t15-;;/m0../s1
• InChIKey: VSHFRHVKMYGBJL-CKUXDGONSA-N

Beschreibung

Allgemeine Beschreibung

Ropivacaine has lidocaine-related structure with tertiary amine side chains. It is a pure S(-)enantiomer with a propyl group on the piperidine nitrogen atom.

Anwendung

Ropivacaine hydrochloride monohydrate has been used as an analyte in tandem mass spectrometry and as an amide-based local anaesthetic to test its effect on breast cancer cell methylation.

Biochem./physiol. Wirkung

Local anaesthetic with less cardiotoxicity than bupivacaine; causes reversible blockade of impulse propagation along nerve fibres by preventing the inward movement of sodium ions through the cell membrane of the nerve fibers.

Ropivacaine less lipophilic as compared with bupivacaine. It is metabolized in the liver by the enzyme cytochrome P4501A2. Ropivacaine elicits less central nervous system (CNS) toxicity and is used as a local anaesthetic during postoperative and labour pain.

Leistungsmerkmale und Vorteile

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS05
• Signalwort: Danger
• H-Sätze: H318
• P-Sätze: P280 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Dam. 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable