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P5234

Sigma-Aldrich

Purvalanol B

≥97% (HPLC), solid

Synonym(e):

(2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol, NG 95

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About This Item

Empirische Formel (Hill-System):
C20H25ClN6O3
CAS-Nummer:
212844-54-7
Molekulargewicht:
432.90
MDL-Nummer:
MFCD04118312
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329820218
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥97% (HPLC)

Form

solid

Löslichkeit

DMSO: soluble 37 mg/mL
H2O: insoluble

Versandbedingung

dry ice

Lagertemp.

−20°C

SMILES String

CC(C)[C@H](CO)Nc1nc(Nc2ccc(C(O)=O)c(Cl)c2)c3ncn(C(C)C)c3n1

InChI

1S/C20H25ClN6O3/c1-10(2)15(8-28)24-20-25-17(16-18(26-20)27(9-22-16)11(3)4)23-12-5-6-13(19(29)30)14(21)7-12/h5-7,9-11,15,28H,8H2,1-4H3,(H,29,30)(H2,23,24,25,26)/t15-/m0/s1

InChIKey

ZKDXRFMOHZVXSG-HNNXBMFYSA-N

Biochem./physiol. Wirkung

Purvalanol B is a cyclin-dependent; 2,6,9-substituted kinase inhibitor.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Voin Petrovic et al.
Nutrients, 10(4) (2018-04-06)
The use of garlic and garlic-based extracts has been linked to decreased incidence of cancer in epidemiological studies. Here we examine the molecular and cellular activities of a simple homemade ethanol-based garlic extract (GE). We show that GE inhibits growth
Voin Petrovic et al.
Analytical biochemistry, 523, 10-16 (2017-02-09)
The Multiplexed Inhibitor Bead (MIB) assay is a previously published quantitative proteomic MS-based approach to study cellular kinomes. A rather extensive procedure, need for multiple custom-made kinase inhibitors and an inability to re-use the MIB-columns, has limited its applicability. Here
Matthew B Lipner et al.
JCI insight, 5(8) (2020-03-28)
Over 55,000 people in the United States are diagnosed with pancreatic ductal adenocarcinoma (PDAC) yearly, and fewer than 20% of these patients survive a year beyond diagnosis. Chemotherapies are considered or used in nearly every PDAC case, but there is
Alison M Kurimchak et al.
Science signaling, 13(619) (2020-02-20)
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological cancer with few effective, targeted therapies. HGSOC tumors exhibit genomic instability with frequent alterations in the protein kinome; however, only a small fraction of the kinome has been therapeutically targeted
Alison M Kurimchak et al.
Molecular cancer research : MCR, 17(8), 1721-1734 (2019-05-03)
Mutation or deletion of Neurofibromin 1 (NF1), an inhibitor of RAS signaling, frequently occurs in epithelial ovarian cancer (EOC), supporting therapies that target downstream RAS effectors, such as the RAF-MEK-ERK pathway. However, no comprehensive studies have been carried out testing
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