P4670

Propafenon -hydrochlorid

• Synonym(e): 1-[2-(2-Hydroxy-3-(propylamino)propoxy)phenyl]-3-phenyl-1-propanone hydrochloride
• Empirische Formel (Hill-System): C₂₁H₂₇NO₃ · HCl
• CAS-Nummer: 34183-22-7
• Molekulargewicht: 377.90
• EG-Nummer: 251-867-9
• MDL-Nummer: MFCD00079243
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 24278636
• NACRES: NA.77

Eigenschaften

• Form: powder
• Qualitätsniveau: 100
• Ersteller: Abbott
• Lagertemp.: 2-8°C
• SMILES String: Cl[H].CCCNCC(O)COc1ccccc1C(=O)CCc2ccccc2
• InChI: 1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H
• InChIKey: XWIHRGFIPXWGEF-UHFFFAOYSA-N
• Angaben zum Gen: human ... ABCB1(5243) , ADRB1(153) , ADRB2(154) , ADRB3(155) , CYP1A2(1544) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

Beschreibung

Allgemeine Beschreibung

Propafenone hydrochloride is a calcium antagonist. It functions as a Na⁺ and K⁺ channel blocker. It might be used to treat patients with systemic hypertension. Propafenone hydrochloride is associated with bradycardia and bronchospasms. It is metabolized in the liver. Propafenone hydrochloride is used to treat ventricular arrhythmias.

Anwendung

Propafenone hydrochloride has been used in the isolation of cardiomyocytes.

Biochem./physiol. Wirkung

Blocks hKv1.5 and ATP-sensitive K⁺ channels; class 1C antiarrhythmic agent that is also an antagonist at β adrenergic receptors.

Leistungsmerkmale und Vorteile

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3