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P4399

Sigma-Aldrich

β-Lactamase aus Enterobacter cloacae

Type III, lyophilized powder, 6-18 units/mg protein (using benzylpenicillin)

Synonym(e):

Cephalosporinase, Penicillin amido-β-lactam hydrolase, Penicillinase aus Enterobacter cloacae

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About This Item

CAS-Nummer:
9073-60-3
EC-Nummer:
3.5.2.6 (BRENDA, IUBMB)
MDL-Nummer:
MFCD00131819
UNSPSC-Code:
12352204
NACRES:
NA.54

Typ

Type III

Form

lyophilized powder

Spezifische Aktivität

6-18 units/mg protein (using benzylpenicillin)

Zusammensetzung

Protein, ~10%

Lagertemp.

2-8°C

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Anwendung

β--lactamase is used to inactivate β-lactam antibiotics by breaking open the β-lactam ring. β--lactamase is used to study antibiotic resistance and resistance suppression. Product P4399 is produced from Enterobacter cloacae.

Biochem./physiol. Wirkung

β--lactamase inactivates β-lactam antibiotics by breaking open the β-lactam ring.

Einheitendefinition

One unit will hydrolyze 1.0 μmole of benzylpenicillin per min at pH 7.0 at 25 °C. This International Unit (using benzylpenicillin as substrate) is approximately equal to 600 Levy or 75 Pollock units.

Physikalische Form

Lyophilized powder containing sodium phosphate and sodium citrate buffer salts

Angaben zur Herstellung

Chromatographically purified

Hinweis zur Analyse

Protein determined by biuret

Inhibitor

Produkt-Nr.
Beschreibung
Preisangaben

D7910

3,4-Dichlorisocumarin, serine protease inhibitor

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H317,H334

Gefahreneinstufungen

Resp. Sens. 1 - Skin Sens. 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Millipore

Millipore

49862

Nitrocefin-Scheiben

Nitrocefin A chromogenic β-lactamase substrate that undergoes distinctive color change from yellow as the amide bond in the β-lactam ring is hydrolyzed by β-lactamase.

Sigma-Aldrich

484400

Nitrocefin

Penicillin-Amidase aus E. coli 5-10 units/mg protein

Sigma-Aldrich

76427

Penicillin-Amidase aus E. coli

P J Johnsen et al.
Genetics, 181(4), 1521-1533 (2009-02-05)
We present a new hypothesis for the selective pressures responsible for maintaining natural competence and transformation. Our hypothesis is based in part on the observation that in Bacillus subtilis, where transformation is widespread, competence is associated with periods of nongrowth
Arnold Louie et al.
Antimicrobial agents and chemotherapy, 56(1), 258-270 (2011-10-26)
New broad-spectrum β-lactamases such as KPC enzymes and CTX-M-15 enzymes threaten to markedly reduce the utility of our armamentarium of β-lactam agents, even our most potent drugs, such as carbapenems. NXL104 is a broad-spectrum non-β-lactam β-lactamase inhibitor. In this evaluation
Ryan M Phelan et al.
Bioorganic & medicinal chemistry letters, 19(4), 1261-1263 (2009-01-27)
An efficient synthesis of a 5-fluorouracil-cephalosporin prodrug is described for use against colorectal and other cancers in antibody and gene-directed therapies. The compound shows stability in aqueous media until specifically activated by beta-lactamase (betaL). The kinetic parameters of the 5-fluorouracil-cephalosporin
Elena De Vecchi et al.
Journal of medical microbiology, 62(Pt 6), 859-863 (2013-03-12)
Urinary tract infections (UTIs) are a common cause of bacteraemia in the elderly and are associated with a high probability of hospitalization. Despite the impact of UTIs on health status and quality of life, a limited number of studies have
A A Alsultan et al.
Journal of medical microbiology, 62(Pt 6), 885-888 (2013-03-23)
Carbapenem-resistant Acinetobacter baumannii is becoming increasingly prevalent in patients with diabetes mellitus in the Middle East. We examined the relationship of these bacteria and their resistance mechanisms to the diabetic disease status of patients in Saudi Arabia. Susceptibilities of 271
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