P4365

PJ-34 hydrochloride hydrate

≥98% (HPLC), powder

• Synonym(e): PARP Inhibitor VIII, PJ 34 HCl, N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-(N,N-dimethylamino)acetamide hydrochloride
• Empirische Formel (Hill-System): C₁₇H₁₇N₃O₂ · HCl · xH₂O
• CAS-Nummer: 344458-15-7
• Molekulargewicht: 331.80 (anhydrous basis)
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24898531
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to yellow
• Löslichkeit: H₂O: 22 mg/mL
• SMILES String: Cl[H].[H]O[H].CN(C)CC(=O)Nc1ccc2NC(=O)c3ccccc3-c2c1
• InChI: 1S/C17H17N3O2.ClH.H2O/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15;;/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22);1H;1H2
• InChIKey: YCALIZUKAFUQCH-UHFFFAOYSA-N

Beschreibung

Anwendung

PJ-34 hydrochloride hydrate has been used:

• as a poly(ADP-ribose) polymerase (PARP) inhibitor 1 in rats to test the effect of PAPR1 in neuropathic pain
• as a component of protein extraction buffer to enable visualization of the high-molecular-weight smear of PARylated proteins in various cell samples
• as PARP inhibitor in murine MLE-12 epithelial cell line

Biochem./physiol. Wirkung

PJ-34 is a prototypic poly(ADP-ribose) polymerase 1 (PARP-1) inhibitor.

PJ-34 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)