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P0643

Sigma-Aldrich

5-Propyl-2-thiouracil

≥98%

Synonym(e):

PTU

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About This Item

Empirische Formel (Hill-System):
C7H10N2OS
CAS-Nummer:
2954-52-1
Molekulargewicht:
170.23
MDL-Nummer:
MFCD00057340
UNSPSC-Code:
41106305
PubChem Substanz-ID:
24898118
NACRES:
NA.51

Biologische Quelle

synthetic (organic)

Assay

≥98%

Form

powder

Löslichkeit

1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow

SMILES String

CCCC1=CNC(=S)NC1=O

InChI

1S/C7H10N2OS/c1-2-3-5-4-8-7(11)9-6(5)10/h4H,2-3H2,1H3,(H2,8,9,10,11)

InChIKey

RWJRFPUNLXBCML-UHFFFAOYSA-N

Anwendung

5-Propyl-2-thiouracil (PTU) is used to induce and study mechanisms of hypothyroidism at the levels of thyroid hormone biosynthesis and gene regulation.

Piktogramme

Health hazard
GHS08

Signalwort

Warning

H-Sätze

H351

P-Sätze

P281

Gefahreneinstufungen

Carc. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Analysenzertifikate (COA)

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Marion F Haug et al.
Frontiers in zoology, 7, 8-8 (2010-03-03)
Visual acuity, the ability of the visual system to distinguish two separate objects at a given angular distance, is influenced by the optical and neuronal properties of the visual system. Although many factors may contribute, the ultimate limit is photoreceptor
Ruby Bansal et al.
Endocrinology, 160(8), 1771-1785 (2019-05-29)
The CLARITY-BPA experiment, a large collaboration between the National Institute of Environmental Health Sciences, the National Toxicology Program, and the US Food and Drug Administration, is designed to test the effects of bisphenol A (BPA) on a variety of endocrine
Alessandra Gentili et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 33(12), 1793-1802 (2016-10-04)
This paper describes a rapid method for confirming residues of thyreostats in meat-based baby foods by using liquid chromatography - dual polarity electrospray - tandem mass spectrometry (LC-ES(±)-MS/MS). Six thioureylenes, belonging to the group of thiouracil and imidazole, were selected
Alexander G Little et al.
BMC biology, 11, 26-26 (2013-03-28)
Thyroid hormone (TH) is best known for its role in development in animals, and for its control of metabolic heat production (thermogenesis) during cold acclimation in mammals. It is unknown whether the regulatory role of TH in thermogenesis is derived
Lihua Liu et al.
Environmental pollution (Barking, Essex : 1987), 219, 1122-1130 (2016-09-13)
Short-chain chlorinated paraffins (SCCPs) are ubiquitous in the environment and might cause adverse environmental and human health effects. Little is known about the relative toxicity of different SCCP compounds especially during development. The objective of this study was to characterize
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