P0543

5-Pregnen-3β-ol-20-one-16α-carbonitrile

≥97%

• Synonym(e): Pregnenolone-16α-carbonitrile
• Empirische Formel (Hill-System): C₂₂H₃₁NO₂
• CAS-Nummer: 1434-54-4
• Molekulargewicht: 341.49
• MDL-Nummer: MFCD00272045
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 24898113
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Sterilität: non-sterile
• Assay: ≥97%
• Form: powder, crystals or chunks
• Methode(n): cell culture | mammalian: suitable
• Löslichkeit: chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow (with heat)
• Versandbedingung: ambient
• Lagertemp.: 2-8°C
• SMILES String: C[C@@]12[C@](C[C@@H](C#N)[C@@H]2C(C)=O)([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC1
• InChI: 1S/C22H31NO2/c1-13(24)20-14(12-23)10-19-17-5-4-15-11-16(25)6-8-21(15,2)18(17)7-9-22(19,20)3/h4,14,16-20,25H,5-11H2,1-3H3/t14-,16-,17+,18-,19-,20-,21-,22-/m0/s1
• InChIKey: VSBHRRMYCDQLJF-ZDNYCOCVSA-N

Beschreibung

Anwendung

5-Pregnen-3β-ol-20-one-16α-carbonitrile has been used:

• in the induction of cytochrome P450
• as pregnane X receptor (PXR) activator in human liver cell lines.

Biochem./physiol. Wirkung

Pregnenolone-16a-carbonitrile (PCN) is a glucocorticoid receptor antagonist and a PXR (pregnane X receptor) activator.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): >199.9 °F - closed cup
• Flammpunkt (°C): > 93.3 °C - closed cup
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)