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N6037

Sigma-Aldrich

Neridronate

≥97% (NMR), solid, bone resorption inhibitor

Synonym(e):

6-Amino-1-hydroxyhexylidene bisphosphonic acid, Neridronic acid, Nerixia

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About This Item

Empirische Formel (Hill-System):
C6H17NO7P2
CAS-Nummer:
79778-41-9
Molekulargewicht:
277.15
MDL-Nummer:
MFCD00866995
UNSPSC-Code:
51111800
PubChem Substanz-ID:
24724553
NACRES:
NA.77

product name

Neridronate, ≥97% (NMR), solid

Beschreibung

may contain <1% (w/w) inorganic salts

Qualitätsniveau

100

Assay

≥97% (NMR)

Form

solid

Farbe

white

Löslichkeit

H2O: >5 mg/mL

Lagertemp.

2-8°C

SMILES String

NCCCCCC(O)(P(O)(O)=O)P(O)(O)=O

InChI

1S/C6H17NO7P2/c7-5-3-1-2-4-6(8,15(9,10)11)16(12,13)14/h8H,1-5,7H2,(H2,9,10,11)(H2,12,13,14)

InChIKey

PUUSSSIBPPTKTP-UHFFFAOYSA-N

Biochem./physiol. Wirkung

Neridronate is a bone resorption inhibitor. It is used to treat Osteogenesis Imperfecta, an "orphan disease" characterized by a fragility of the bone enough to be named the "illness of bones of crystal".

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Etidronate disodium hydrate &#8805;97% (NMR), solid

Sigma-Aldrich

P5248

Etidronate disodium hydrate

Alendronat-Natrium Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1599

Alendronat-Natrium

Zoledronsäure Monohydrat &#8805;98% (HPLC)

Sigma-Aldrich

SML0223

Zoledronsäure Monohydrat

Zoledronsäure United States Pharmacopeia (USP) Reference Standard

USP

1724827

Zoledronsäure

Pietro Persiani et al.
Medicine, 96(20), e6766-e6766 (2017-05-18)
The purpose of this study is to compare the results of 2 techniques, tension band wiring (TBW) and fixation with screws, in olecranon fractures in children affected with osteogenesis imperfecta (OI) type I. Between 2010 and 2014, 21 olecranon fractures
Yasmina Hamdous et al.
Journal of nanobiotechnology, 15(1), 74-74 (2017-10-19)
Biologics magnetics nanoparticles, magnetosomes, attract attention because of their magnetic characteristics and potential applications. The aim of the present study was to develop and characterize novel magnetosomes, which were extracted from magnetotactic bacteria, purified to produce apyrogen magnetosome minerals, and
M Benucci et al.
Clinical and experimental rheumatology, 27(4), 567-573 (2009-09-24)
To assess the effects of intramuscular (im) neridronate (NE) on lumbar and femoral neck BMD and on markers of bone turnover in rheumatic patients under chronic low-dose glucocorticoids (GC) therapy. Sixty-nine osteopoenic and osteoporotic patients, affected by rheumatic diseases and
Silvano Adami et al.
Calcified tissue international, 83(5), 301-307 (2008-10-24)
Compliance to osteoporosis treatment with oral bisphosphonates is very poor. Intermittent intravenous bisphosphonate is a useful alternative, but this route is not readily available. Neridronate, a nitrogen-containing bisphosphonate that can be given intramuscularly (IM), was tested in a phase 2
Luigi Gennari et al.
Mini reviews in medicinal chemistry, 9(9), 1052-1063 (2009-08-20)
Paget's disease of bone is a focal skeletal disorder characterized by the formation of structurally abnormal bone, deformity and other complications leading to significant disability and bone pain. Recently, the availability of newer, more potent nitrogen-containing bisphosphonates has improved treatment
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