N5636

3-Nitropropionsäure

≥97% (HPLC), powder or crystals, mitochondrial complex II inhibitor

• Lineare Formel: O₂N(CH₂)₂CO₂H
• CAS-Nummer: 504-88-1
• Molekulargewicht: 119.08
• Beilstein: 1759889
• EG-Nummer: 208-003-0
• MDL-Nummer: MFCD00007406
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278593
• NACRES: NA.77

Eigenschaften

• product name: 3-Nitropropionsäure, ≥97%
• Biologische Quelle: synthetic
• Assay: ≥97%
• Form: powder or crystals
• Farbe: white to light yellow
• mp (Schmelzpunkt): 68-70 °C (lit.)
• Löslichkeit: alcohol: may be light yellow 100 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: OC(CC[N+]([O-])=O)=O
• InChI: 1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)
• InChIKey: WBLZUCOIBUDNBV-UHFFFAOYSA-N

Beschreibung

Anwendung

3-Nitropropionic acid has been used:

• to generate multiple system atropy-parkinsoniam (MSA-P) model in rat to evaluate its effect on embryonic striatal and mesencephalic grafts
• to inject into the nigrostriatal dopaminergic pathway in rats in order to examine its specific effects on the dopamine system
• as succinate dehydrogenase (SDH) inhibitor for LUHMES neurons and cell lines

Biochem./physiol. Wirkung

Administering 3-nitropropionic acid (3-NP) to the inner ear can stimulate sensorineural hearing loss. It serves as an irreversible inhibitor of mitochondrial complex II.

Excitotoxin shown to cause brain lesions similar to those of Huntington′s disease.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P301 + P330 + P331 + P310
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges