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N5504

Sigma-Aldrich

Naphazolin -hydrochlorid

Synonym(e):

2-(1-Naphthylmethyl)-imidazolin -hydrochlorid

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About This Item

Empirische Formel (Hill-System):
C14H14N2 · HCl
CAS-Nummer:
550-99-2
Molekulargewicht:
246.74
EG-Nummer:
208-989-2
MDL-Nummer:
MFCD00012554
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278592
NACRES:
NA.77

Form

powder

Ersteller

Allergan

SMILES String

Cl.C1CN=C(Cc2cccc3ccccc23)N1

InChI

1S/C14H14N2.ClH/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;/h1-7H,8-10H2,(H,15,16);1H

InChIKey

DJDFFEBSKJCGHC-UHFFFAOYSA-N

Angaben zum Gen

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

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Biochem./physiol. Wirkung

Naphazoline hydrochloride is a sympathomimetic agent. It is also considered as a conjunctival decongestant.
α-adrenoceptor agonist; imidazoline receptor agonist; vasoconstrictor.

Leistungsmerkmale und Vorteile

This compound was developed by Allergan. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Nan-Nan Wang et al.
Luminescence : the journal of biological and chemical luminescence, 24(3), 178-182 (2009-03-03)
A sensitive and simple flow-injection chemiluminescence (FI-CL) method, which was based on the CL intensity generated from the redoxreaction of potassium permanganate (KMnO4)-formaldehyde in vitriol (H2SO4) medium, has been developed, validated and applied for the determination of naphazoline hydrochloride and
Marie Granier et al.
Canadian journal of anaesthesia = Journal canadien d'anesthesie, 56(2), 102-108 (2009-02-28)
Septorhinoplasty is a traumatic procedure that is associated with epistaxis and postoperative pain. The primary objective of this randomized double-blind controlled trial was to determine whether intranasal 5% lidocaine plus naphazoline decreases postoperative pain and lessens the use of rescue
M Gelardi et al.
Journal of biological regulators and homeostatic agents, 23(2), 79-84 (2009-07-11)
A wide variety of nasal irrigation systems are currently available for improving nasal symptoms, but few studies have compared their effectiveness with respect to patient age and type of nasal disease. This pilot study aims to compare the efficacy of
Yuriko Nagane et al.
Muscle & nerve, 44(1), 41-44 (2011-04-15)
When treating ocular myasthenia gravis (MG), the risk/benefit profile of corticosteroids is unclear, and acetylcholinesterase inhibitors are not very effective. We examined the efficacy of topical naphazoline in the treatment of myasthenic blepharoptosis. Sixty MG patients with blepharoptosis (32 with
Arzu Karakurt et al.
European journal of medicinal chemistry, 57, 275-282 (2012-10-23)
Twenty-three new oxime ester derivatives of nafimidone were synthesized with the prospect of potential anticonvulsant activities. MES and ScM tests were employed for their anticonvulsant activities and rotorod test for neurological deficits. Eighteen compounds were found to be protective against
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