N1790

Naftifin -hydrochlorid

• Synonym(e): Naftifine HCL
• Empirische Formel (Hill-System): C₂₁H₂₁N · HCl
• CAS-Nummer: 65473-14-5
• Molekulargewicht: 323.86
• MDL-Nummer: MFCD00059047
• UNSPSC-Code: 51102829
• PubChem Substanz-ID: 329818590
• NACRES: NA.76

Eigenschaften

• Assay: ≥99%
• Qualitätsniveau: 200
• Form: powder
• Löslichkeit: ethanol: soluble 50 mg/mL
• Wirkungsspektrum von Antibiotika: Gram-negative bacteria; Gram-positive bacteria; fungi; yeast
• Wirkungsweise: cell wall synthesis | interferes; enzyme | inhibits
• Lagertemp.: 2-8°C
• SMILES String: Cl.CN(C\C=C\c1ccccc1)Cc2cccc3ccccc23
• InChI: 1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;
• InChIKey: OLUNPKFOFGZHRT-YGCVIUNWSA-N

Beschreibung

Anwendung

Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. It is used topically to treat superficial dermatomycoses such as tinea pedis, tinea cruris, and tinea corporis.

Biochem./physiol. Wirkung

Naftifine is an allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria. It has demonstrated anti-inflammatory properties such as a reduction in superoxide production and a reduction in polymorphonuclear leukocyte chemotaxis/endothelial adhesion. Naftifine appears to interfere with sterol biosynthesis by inhibiting the squalene 2,3-epoxidase. This inhibition results in decreased amounts of ergosterol and an accumulation of squalene in the cells.

Allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria and has demonstrated anti-inflammatory properties.

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place.Light sensitive.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable