M7898

Monoclonal Anti-Thy 1.1 antibody produced in mouse

clone TN-26, purified immunoglobulin, buffered aqueous solution

• Synonym(e): Anti-CD90, Anti-CDw90
• MDL-Nummer: MFCD00164701
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: TN-26, monoclonal
• Form: buffered aqueous solution
• Speziesreaktivität: mouse
• Methode(n): complement-mediated cytotoxicity assay: suitable; indirect immunofluorescence: suitable
• Isotyp: IgM
• UniProt-Hinterlegungsnummer: P01831
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: mouse ... Thy1(21838)

Beschreibung

Allgemeine Beschreibung

Monoclonal Anti-Thy 1.1 (mouse IgM isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.

Thymus cell antigen 1 (Thy 1.1) is a glycosylphosphatidyl-anchored protein. It belongs to the of the immunoglobulin superfamily. Thy 1.1 is expressed in stem cells, T-cells and neurons.

Spezifität

Recognizes Thy 1.1 bearing cells and is less than 5% cross-reactive with Thy 1.2 bearing cells. Titer is 1:20,000 as determined by in vitro cytotoxicity against AKR/J thymocytes.

Immunogen

thymocytes from AKR/J (Thy 1.1) mice.

Anwendung

Monoclonal Anti-Thy 1.1 antibody produced in mouse has been used in immunopanning and immunofluorescence.

Biochem./physiol. Wirkung

Studies have shown that mice lacking the protein thymus cell antigen 1 (Thy 1.1) have an increased number of fibroblasts. It suppresses proliferation and enhances apoptosis in dermal fibroblasts, thereby modulating cell growth. This is carried out by regulating the action of β3 integrin.

Physikalische Form

Solution in 0.1 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable