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M4537
Mycolsäure aus Mycobacterium tuberculosis (Rinder-Stamm)
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About This Item
Empfohlene Produkte
Biologische Quelle
Mycobacterium tuberculosis (bovine strain)
Beschreibung
mixture of homologous acids
Form
powder
Funktionelle Gruppe
carboxylic acid
Lipid-Typ
unsaturated FAs
Lagertemp.
−20°C
Biochem./physiol. Wirkung
Mycolic acids are long chain fatty acid containing molecules found in the cell walls of mycolata taxon bacteria. Mycolic acid from Mycobacterium tuberculosis (bovine strain) may be used to study mechanisms of resistance to antibiotic drug treatment and the toxicity of tuberculosis bacteria.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Guanghou Shui et al.
EMBO molecular medicine, 4(1), 27-37 (2011-12-08)
Mycolic acids are attractive diagnostic markers for tuberculosis (TB) infection because they are bacteria-derived, contain information about bacterial species, modulate host-pathogen interactions and are chemically inert. Here, we present a novel approach based on mass spectrometry. Quantification of specific precursor
Asselineau, J.
The Bacterial Lipids, - (1962)
Mervyn Beukes et al.
Chemistry and physics of lipids, 163(8), 800-808 (2010-09-30)
Cell wall mycolic acids (MA) from Mycobacterium tuberculosis (M.tb) are CD1b presented antigens that can be used to detect antibodies as surrogate markers of active TB, even in HIV coinfected patients. The use of the complex mixtures of natural MA
Kapil Tahlan et al.
Antimicrobial agents and chemotherapy, 56(4), 1797-1809 (2012-01-19)
SQ109, a 1,2-diamine related to ethambutol, is currently in clinical trials for the treatment of tuberculosis, but its mode of action remains unclear. Here, we demonstrate that SQ109 disrupts cell wall assembly, as evidenced by macromolecular incorporation assays and ultrastructural
Anna E Grzegorzewicz et al.
Nature chemical biology, 8(4), 334-341 (2012-02-22)
New chemotherapeutics active against multidrug-resistant Mycobacterium tuberculosis are urgently needed. We report on the identification of an adamantyl urea compound that shows potent bactericidal activity against M. tuberculosis and a unique mode of action, namely the abolition of the translocation
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