L1378
L-Milch-Dehydrogenase aus Rindermuskel
Type X, ammonium sulfate suspension, ≥600 units/mg protein
Synonym(e):
L-LDH
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About This Item
Empfohlene Produkte
Biologische Quelle
bovine muscle
Qualitätsniveau
Typ
Type X
Assay
3.0—25.0 mg protein/mL (biuret)
Form
ammonium sulfate suspension
Spezifische Aktivität
≥600 units/mg protein
Hersteller/Markenname
Sigma-Aldrich
Methode(n)
activity assay: suitable
Farbe
white
pH-Wert
7.5
Anwendung(en)
life science and biopharma
Fremdaktivität
pyruvate kinase ≤0.01%
Lagertemp.
2-8°C
Angaben zum Gen
cow ... LDHA(281274) , LDHB(281275)
Allgemeine Beschreibung
Research Area: Cell Signaling
Lactate dehydrogenase (LDH) is a key enzyme in the anaerobic metabolic pathway and falls under the class of oxidoreductases. This enzyme is found in a wide range of organisms, including both plants and animals. It is widely distributed across all tissues. LDH is primarily a cytoplasmic enzyme, with particularly high concentrations in muscle, liver, and kidney tissues.
Lactate dehydrogenase (LDH) is a key enzyme in the anaerobic metabolic pathway and falls under the class of oxidoreductases. This enzyme is found in a wide range of organisms, including both plants and animals. It is widely distributed across all tissues. LDH is primarily a cytoplasmic enzyme, with particularly high concentrations in muscle, liver, and kidney tissues.
Anwendung
L-Lactic Dehydrogenase from bovine muscle has been used in lactate assay to assess lactate tissue accumulation.
Biochem./physiol. Wirkung
Lactate dehydrogenase (LDH) plays a critical role as a checkpoint in gluconeogenesis and DNA metabolism. It plays a vital role in maintaining homeostasis during periods of low oxygen availability. As an oxidoreductase enzyme, lactate dehydrogenase catalyzes the reversible conversion of pyruvate to lactate using NADH. This enzyme is crucial for the anaerobic metabolism of glucose when oxygen is either absent or in short supply. LDH is the sole serum biomarker effective for evaluating metastatic melanomas.
Also catalyzes the oxidation of other L-2-hydroxymonocarboxylic acids.
Einheitendefinition
One unit will reduce 1.0 μmole of pyruvate to L-lactate per min at pH 7.5 at 37 °C.
Physikalische Form
Crystalline suspension in 2.4 M (NH4)2SO4 solution, pH 6.0
Hinweis zur Analyse
Protein determined by biuret.
Signalwort
Danger
H-Sätze
P-Sätze
Gefahreneinstufungen
Resp. Sens. 1
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 1
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
Analysenzertifikate (COA)
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Artikel
Instructions for working with enzymes supplied as ammonium sulfate suspensions
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