I1411

ITX3

≥98% (HPLC)

• Synonym(e): 2-[(2,5-Dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene]-thiazolo[3,2-a]benzimidazol-3(2H)-one
• Empirische Formel (Hill-System): C₂₂H₁₇N₃OS
• CAS-Nummer: 347323-96-0
• Molekulargewicht: 371.45
• MDL-Nummer: MFCD02629172
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 329815351
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Löslichkeit: DMSO: ≥4 mg/mL
• Lagertemp.: room temp
• SMILES String: Cc1cc(\C=C2\Sc3nc4ccccc4n3C2=O)c(C)n1-c5ccccc5
• InChI: 1S/C22H17N3OS/c1-14-12-16(15(2)24(14)17-8-4-3-5-9-17)13-20-21(26)25-19-11-7-6-10-18(19)23-22(25)27-20/h3-13H,1-2H3/b20-13+
• InChIKey: SJMYMKPBODEZSH-DEDYPNTBSA-N

Beschreibung

Biochem./physiol. Wirkung

ITX3 is a specific inhibitor of endogenous TrioN activity acting on the GEF domain and selective cell active inhibitor of the Trio/RhoG/Rac1 pathway. The compound is active in whole cell assay where it inhibits the formation of TrioN-dependent cell structures. ITX3 appears to be specific for TrioN inhibition rather than other RhoGEFs.

ITX3 is a specific inhibitor of endogenous TrioN activity; selective cell active inhibitor of the Trio/RhoG/Rac1 pathway.

Leistungsmerkmale und Vorteile

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GTP Binding Proteins (Low Molecular Weight) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable