H9384

22(R)-Hydroxycholesterin

≥98%

• Synonym(e): 22α-Hydroxycholesterol, 5-Cholestene-3β,22(R)-diol, 5-Cholestene-3β,22[R]-diol
• Empirische Formel (Hill-System): C₂₇H₄₆O₂
• CAS-Nummer: 17954-98-2
• Molekulargewicht: 402.65
• MDL-Nummer: MFCD00070042
• UNSPSC-Code: 12352211
• eCl@ss: 39023139
• PubChem Substanz-ID: 24895852
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥98%
• Form: powder
• Versandbedingung: ambient
• Lagertemp.: room temp
• SMILES String: [H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])[C@H](C)[C@H](O)CCC(C)C
• InChI: 1S/C27H46O2/c1-17(2)6-11-25(29)18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20-,21-,22+,23-,24-,25+,26-,27+/m0/s1
• InChIKey: RZPAXNJLEKLXNO-GFKLAVDKSA-N

Beschreibung

Anwendung

Bovine aortic endothelial cells were treated with 22(R)-Hydroxycholesterol to study the effects on production of free radicals and in studies related to fatty acid metabolism.

Biochem./physiol. Wirkung

22(R)-Hydroxycholesterol is an intermediate of the pregnenolone synthesis pathway from cholesterol. It reported has neuroprotective properties and protects the neurons against β-amyloid-induced cell death. 22(R)-Hydroxycholesterol acts as the ligand of liver X receptors that act as sensors of sterol concentration and regulates the fatty acid metabolism.

Angaben zur Herstellung

22(R)-Hydroxycholesterol yield clear, colorless solution in chloroform.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)