H6041

Interferon α 2A human

HumanKine^®, ≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyopholized powder, suitable for cell culture

• Synonym(e): α 2A Interferon, Human Interferon α 2A, IFN-α 2A
• UNSPSC-Code: 12352202
• NACRES: NA.77

Eigenschaften

• product name: Interferon α 2A human, IFN-α 2A, recombinant, expressed in HEK 293 cells, HumanKine^®, suitable for cell culture
• Biologische Quelle: human
• Qualitätsniveau: 100
• Rekombinant: expressed in HEK 293 cells
• Assay: ≥95% (SDS-PAGE)
• Form: lyophilized powder
• Wirksamkeit: ≤0.4 ng/mL EC₅₀
• Qualität: endotoxin tested
• Mol-Gew.: monomer 16 kDa (glycosylated)
• Verpackung: glass bottle of 10 μg (in glass bottle)
• Hersteller/Markenname: HumanZyme
• Methode(n): cell culture | mammalian: suitable
• Verunreinigungen: ≤1EU/mg
• UniProt-Hinterlegungsnummer: P01563
• Lagertemp.: −20°C
• Angaben zum Gen: human ... IFNA2(3440)

Beschreibung

Allgemeine Beschreibung

The IFNA2 (interferon alpha 2) gene is mapped to human chromosome 9p21.3. It is considered to be a prototypic type I IFN subtype. The encoded protein contains 165 amino acid. Ifna2 protein structure possesses five α-helices, linked by two disulfide bonds.

Anwendung

Interferon α 2A human has been used to check its antiviral action against chikungunya virus. It has also been used as a control to check the antiviral cytokine induction of Korean red ginseng.

Biochem./physiol. Wirkung

IFNA2 is a type 1 interferon which acts as the first line of defense, and offers protection against pathogenic invasion.

Interferon α 2A (IFN-α 2A) belongs to the type I interferon protein family and is produced by many cell types in response to viral infection. It has antiproliferative and antitumor activities, as well as induction of apoptosis and the inflammatory response. IFN-α 2A enhances the expression of MHC proteins by increasing the presentation of antigen peptides and activates cytotoxic T cells.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution of 1x PBS.

Angaben zur Herstellung

HumanKine IFN-α 2A, expressed in human HEK 293 cells, is a glycosylated monomer with an apparent molecular mass of 16 kDa. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

Hinweis zur Analyse

The activity is determined by the dose-dependent cytotoxicity of the human TF-1 cell line (human erythroleukemic indicator cell line)) ≤ 0.4.

Rechtliche Hinweise

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable