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H4663

Sigma-Aldrich

HMBA

≥98% (HPLC), solid

Synonym(e):

10-[(3-Hydroxy-4-methoxybenzylidene)]-9(10H)-anthracenone

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About This Item

Empirische Formel (Hill-System):
C22H16O3
CAS-Nummer:
564468-51-5
Molekulargewicht:
328.36
MDL-Nummer:
MFCD06411568
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24724500
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

solid

Löslichkeit

DMSO: soluble 34 mg/mL

Lagertemp.

−20°C

SMILES String

COc1ccc(cc1O)\C=C2\c3ccccc3C(=O)c4ccccc24

InChI

1S/C22H16O3/c1-25-21-11-10-14(13-20(21)23)12-19-15-6-2-4-8-17(15)22(24)18-9-5-3-7-16(18)19/h2-13,23H,1H3

InChIKey

MQLACMBJVPINKE-UHFFFAOYSA-N

Biochem./physiol. Wirkung

HMBA is an Inhibitor of microtubule polymerization; apoptosis inducer.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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Erwan Dupuis et al.
Talanta, 219, 121345-121345 (2020-09-06)
Capillary electrophoresis (CE) was hyphenated to multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS) to determine the model age of a highly enriched uranium (HEU) sample using the 234U/230Th radiochronometer. The use of hydroxymethylbutyric acid (HMBA) as the CE electrolyte was
Yan Wang et al.
Pharmaceutical research, 31(12), 3538-3548 (2014-06-20)
To determine the effect of PEG modification on pharmacologic and gene delivery properties of polymeric CXCR4 antagonist based on Plerixafor. Polymeric Plerixafor (PAMD) was synthesized from Plerixafor (AMD3100) and grafted with different amounts of PEG (2 kDa). CXCR4 antagonism of the
Dong-Hui Xu et al.
International journal of oncology, 45(1), 264-272 (2014-05-03)
Nucleophosmin (NPM, also known as B23), mainly localized in the nucleolus, has been reported to be overexpressed in many types of human cancer, including colon, ovarian, prostate and gastric cancer. NPM was identified while screening the differential nuclear matrix proteins
Olga S Safronova et al.
Nucleic acids research, 42(14), 8954-8969 (2014-07-25)
Hypoxia is associated with a variety of physiological and pathological conditions and elicits specific transcriptional responses. The elongation competence of RNA Polymerase II is regulated by the positive transcription elongation factor b (P-TEFb)-dependent phosphorylation of Ser2 residues on its C-terminal
Ioannis S Vizirianakis et al.
International journal of oncology, 47(1), 303-314 (2015-05-23)
Impairment of ribosome biogenesis contributes to the molecular pathophysiology of ribosomopathies by deregulating cell-lineage specific proliferation, differentiation and apoptosis decisions of haematopoietic progenitor cells. Here, using pro-erythroblast-like murine erythroleukemia (MEL) cells, a model system of erythroid maturation, we aimed to
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