H0266
Hemoglobin A2, Ferrous Stabilized human
lyophilized powder
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About This Item
CAS-Nummer:
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352202
eCl@ss:
42030116
NACRES:
NA.61
Empfohlene Produkte
Biologische Quelle
human
Qualitätsniveau
Assay
97-100% (agarose gel electrophoresis)
Form
lyophilized powder
Methode(n)
immunofluorescence: suitable
Eignung
suitable for electrophoresis and chromatography standard
UniProt-Hinterlegungsnummer
Lagertemp.
−20°C
Angaben zum Gen
human ... HBA2(3040)
Allgemeine Beschreibung
has not been tested for functional equivalence against native preparations (unlyophilized ferrous hemoglobins).
Hemoglobin A2 (HBA2) is mapped to human chromosome 16p13.3. HBA2 is a minor hemoglobin component and comprises of two α and δ chains.
Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide.
Anwendung
Hemoglobin A2 was used in the determination of fetal hemoglobin by time-resolved immunofluorometric assay.
Hemoglobin A2, Ferrous Stabilized human has been used as a reference in reversed-phase high-performance liquid chromatography for quantifying δ-globin elution profile. It has also been used as calibrator in isotope dilution mass spectrometry (IDMS) measurements.
Biochem./physiol. Wirkung
Elevated levels of Hemoglobin A2 (HBA2) is observed in patients with β-thalassemia trait.
Verpackung
Package size indicates the amount of hemoglobin as determined by the procedure of Drabkin, D.L., J. Biol. Chem., 164, 703 (1946).
Rekonstituierung
When reconstituted with buffer, gives >90% ferrous hemoglobin.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Iron deficiency (IDA) and beta thalassemia trait (TT) are the most common causes of hypochromia and microcytosis. Many indices have been defined to quickly discriminate these similar entities via parameters obtained from automated blood cell analyzers. However, studies in the
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To screen immediate family members of thalassaemia patients for carrier identification and counselling. The cross-sectional study was conducted at an urban thalassaemia treatment and prevention centre in Karachi, Pakistan, from January to December 2008, and involved 188 siblings of 100
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