G8171

Gamboginsäure

≥95% (HPLC), powder

• Synonym(e): β-Guttiferin
• Empirische Formel (Hill-System): C₃₈H₄₄O₈
• CAS-Nummer: 2752-65-0
• Molekulargewicht: 628.75
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329799975

Eigenschaften

• Assay: ≥95% (HPLC)
• Form: powder
• Farbe: yellow to orange
• Löslichkeit: DMSO: ≥10 mg/mL; H₂O: insoluble
• Lagertemp.: −20°C
• SMILES String: C\C(C)=C\CC[C@@]1(C)Oc2c(C\C=C(\C)C)c3O[C@@]45[C@@H]6C[C@@H](C=C4C(=O)c3c(O)c2C=C1)C(=O)[C@]5(C\C=C(\C)C(O)=O)OC6(C)C
• InChI: 1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-/t23-,27+,36-,37+,38-/m1/s1
• InChIKey: GEZHEQNLKAOMCA-RRZNCOCZSA-N

Beschreibung

Biochem./physiol. Wirkung

Gambogic acid acts as a caspase activator and apoptosis inducer, which causes an irreversible arrest in the G2/M phase of the cell cycle.

Leistungsmerkmale und Vorteile

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301,H315,H319,H335
• P-Sätze: P261 - P264 - P270 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges