E9386

5-Ethyl-2′-deoxyuridine

• Synonym(e): EUdR, Edoxudine
• Empirische Formel (Hill-System): C₁₁H₁₆N₂O₅
• CAS-Nummer: 15176-29-1
• Molekulargewicht: 256.26
• EG-Nummer: 239-226-1
• MDL-Nummer: MFCD00079191
• UNSPSC-Code: 41106305
• PubChem Substanz-ID: 24894696
• NACRES: NA.51

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Qualitätsniveau: 200
• Assay: ≥95% (HPLC)
• Form: powder
• Löslichkeit: water: 50 mg/mL, clear, colorless to yellow
• Lagertemp.: −20°C
• SMILES String: CCC1=CN(C2CC(O)C(CO)O2)C(=O)NC1=O
• InChI: 1S/C11H16N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h4,7-9,14-15H,2-3,5H2,1H3,(H,12,16,17)
• InChIKey: XACKNLSZYYIACO-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

5-Ethyl-2′-deoxyuridine (EUdR) is used as a 5-fluorouracil (FU) modulator. EtdUrd may be used to enhance the therapeutic index of 5-FU by reducing the catabolism, prolonging the plasma and intratumoral concentrations of 5-FU, and offering protection to normal organs by increasing the endogenous uridine levels.

5-Ethyl-2′-deoxyuridine is an analog of pyrimidine, uridine. It is an effective antiviral agent and inhibits cell division in leukemic tumor cells. 5-Ethyl-2′-deoxyuridine interacts with 2′-deoxycytidine phosphate (dCTP) biosynthesis pathway to elicit antiproliferative effects.

Verlinkung

Homolog of thymidine

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)