D4526

Doxepin -hydrochlorid

~85% E-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder

• Synonym(e): 11-(3-Dimethylaminopropyliden)-6,11-dihydrodibenz[b,e]oxepin -hydrochlorid
• Empirische Formel (Hill-System): C₁₉H₂₁NO · HCl
• CAS-Nummer: 1229-29-4
• Molekulargewicht: 315.84
• EG-Nummer: 214-966-8
• MDL-Nummer: MFCD00079135
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278093
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥98% (GC)
• Form: powder
• Zusammensetzung: Z-isomer, 15% ; E-isomer, ~85%
• Farbe: white to off-white
• Löslichkeit: 1 M HCl: 50 mg/mL; H₂O: soluble
• Ersteller: Boehringer Ingelheim
• SMILES String: Cl[H].CN(C)CC\C=C1/c2ccccc2COc3ccccc13
• InChI: 1S/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11+;
• InChIKey: MHNSPTUQQIYJOT-SJDTYFKWSA-N
• Angaben zum Gen: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133) , HRH1(3269) , HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363)

Beschreibung

Allgemeine Beschreibung

Doxepin is used to treat chronic idiopathic urticaria, chronic pain and anxiety. Doxepin exhibits antiserotonergic properties.

Biochem./physiol. Wirkung

Tricyclic antidepressant that is a more potent inhibitor of norepinephrine uptake than of serotonin uptake; antagonist at H₁ histamine, muscarinic cholinergic, and α-adrenoreceptors.

Leistungsmerkmale und Vorteile

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sonstige Hinweise

Mixture of cis- and trans-isomers

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P264 - P270 - P301 + P310 - P405 - P501
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges