SML0474

(S)-Duloxetin -hydrochlorid

≥98% (HPLC)

• Synonym(e): (γS)-N-Methyl-γ-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride, (+)-(S)-N-Methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine hydrochloride, (+)-N-Methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine hydrochloride, LY-248686 hydrochloride
• Empirische Formel (Hill-System): C₁₈H₁₉NOS · HCl
• CAS-Nummer: 136434-34-9
• Molekulargewicht: 333.88
• MDL-Nummer: MFCD06407958
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825429
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D +116 to +125°, c = 1 in methanol
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: H₂O: 5 mg/mL (clear solution, warmed)
• Lagertemp.: room temp
• SMILES String: Cl.CNCC[C@H](Oc1cccc2ccccc12)c3cccs3
• InChI: 1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m0./s1
• InChIKey: BFFSMCNJSOPUAY-LMOVPXPDSA-N
• Angaben zum Gen: human ... SLC6A2(6530) , SLC6A4(6532)

Beschreibung

Allgemeine Beschreibung

(S)-Duloxetine hydrochloride belongs to the class of serotonin and norepinephrine reuptake inhibitors. Duloxetine is a thiophene derivative. It is used to treat stress urinary incontinence, psychiatric and metabolic disorders. It is also used for treating diabetic peripheral neuropathic pain, fibromyalgia, chronic musculoskeletal and low back pain (LBP). Duloxetine is a cytochrome P450 2D6 (CYP2D6) inhibitor.

Anwendung

(S)-Duloxetine hydrochloride has been used as an antidepressant in rats exposed to chronic mild stress (CMS).

Biochem./physiol. Wirkung

Duloxetine hydrochloride is a dual serotonin/norepinephrine reuptake inhibitor (SNRI), widely used clinically as an antidepressant and anxiolytic.

Duloxetine hydrochloride is a dual serotonin/norepinephrine reuptake inhibitor (SNRI); antidepressant; anxiolytic.

Leistungsmerkmale und Vorteile

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Vorsicht

air sensitive

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable