C9847

Cyclothiazid

• Synonym(e): 6-Chlor-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2-4-benzothiadiazin-7-sulfonamid-1,1-dioxid
• Empirische Formel (Hill-System): C₁₄H₁₆ClN₃O₄S₂
• CAS-Nummer: 2259-96-3
• Molekulargewicht: 389.88
• EG-Nummer: 218-859-7
• MDL-Nummer: MFCD00210192
• UNSPSC-Code: 12352125
• PubChem Substanz-ID: 24278350
• NACRES: NA.77

Eigenschaften

• Form: powder
• Qualitätsniveau: 200
• Ersteller: Eli Lilly
• Lagertemp.: 2-8°C
• SMILES String: [H][C@@]12CC(C3Nc4cc(Cl)c(cc4S(=O)(=O)N3)S(N)(=O)=O)[C@@]([H])(C1)C=C2
• InChI: 1S/C14H16ClN3O4S2/c15-10-5-11-13(6-12(10)23(16,19)20)24(21,22)18-14(17-11)9-4-7-1-2-8(9)3-7/h1-2,5-9,14,17-18H,3-4H2,(H2,16,19,20)/t7-,8+,9?,14?/m0/s1
• InChIKey: BOCUKUHCLICSIY-QJWLJZLASA-N
• Angaben zum Gen: human ... CA1(759) , CA4(762) , GRIA1(2890) , GRIA2(2891) , GRIA3(2892) , GRIA4(2893) ; rat ... Gria1(50592)

Beschreibung

Allgemeine Beschreibung

Cyclothiazide is a benzothiadiazine, which has a similar structure to diazoxide.

Anwendung

Cyclothiazide has been used as a α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) desensitization blocker to study the effects of γ2 on receptor desensitization.

Biochem./physiol. Wirkung

Blocks the rapid desensitization of the AMPA glutamate receptors and markedly prolongs the decay time of the evoked excitatory post-synaptic current.

Leistungsmerkmale und Vorteile

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves