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C9635

Sigma-Aldrich

DL-4-Chloramphetamin -hydrochlorid

≥94% (HPLC)

Synonym(e):

4-Chloro-α-methylphenethylamine hydrochloride, PCA

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About This Item

Lineare Formel:
ClC6H4CH2CH(CH3)NH2·HCl
CAS-Nummer:
3706-38-5
Molekulargewicht:
206.11
MDL-Nummer:
MFCD00013014
UNSPSC-Code:
12352103
PubChem Substanz-ID:
24893180
NACRES:
NA.77

Assay

≥94% (HPLC)

Form

powder

drug control

Home Office Schedule 1; regulated under CDSA - not available from Sigma-Aldrich Canada

Farbe

white to off-white

mp (Schmelzpunkt)

168-170 °C (lit.)

Löslichkeit

DMSO: >20 mg/mL
H2O: >20 mg/mL

Lagertemp.

−20°C

SMILES String

Cl.CC(N)Cc1ccc(Cl)cc1

InChI

1S/C9H12ClN.ClH/c1-7(11)6-8-2-4-9(10)5-3-8;/h2-5,7H,6,11H2,1H3;1H

InChIKey

DZAANUYJOGCNLL-UHFFFAOYSA-N

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Biochem./physiol. Wirkung

Neurotoxic on prolonged administration or at high dosage; substrate for the serotonin transporter that releases serotonin from axon terminals by a nonexocytotic mechanism and blocks the reuptake of serotonin; inhibits tryptophan hydroxylase.

Piktogramme

Skull and crossbonesHealth hazard
GHS06,GHS08

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Repr. 2 - STOT RE 2 - STOT SE 3

Zielorgane

Brain, Central nervous system

Lagerklassenschlüssel

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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P Scholze et al.
The Journal of pharmacology and experimental therapeutics, 293(3), 870-878 (2000-06-28)
HEK 293 cells stably expressing the human serotonin transporter (hSERT) were grown on coverslips, preincubated with [(3)H]5-hydroxytryptamine (5-HT), and superfused. Substrates of the hSERT [e.g., p-chloroamphetamine (PCA)], increased the basal efflux of [(3)H]5-HT in a concentration-dependent manner. 5-HT reuptake blockers
Joke Baute et al.
Genome biology, 16, 168-168 (2015-09-12)
To sustain the global requirements for food and renewable resources, unraveling the molecular networks underlying plant growth is becoming pivotal. Although several approaches to identify genes and networks involved in final organ size have been proven successful, our understanding remains
Sander Biesbroek et al.
The American journal of clinical nutrition, 102(1), 146-154 (2015-05-15)
Several methods are used to determine dietary patterns. Hybrid methods incorporate information on nutrient intake or biological factors to extract patterns relevant to disease etiology. We explore differences between patterns derived with 2 hybrid methods with those obtained by a
H Harrington Cleveland et al.
Development and psychopathology, 27(1), 51-67 (2015-02-03)
Data drawn from the in-home subsample of the PROSPER intervention dissemination trial were used to investigate the moderation of intervention effects on underage alcohol use by maternal involvement and candidate genes. The primary gene examined was dopamine receptor D4 (DRD4).
M Réblová et al.
Persoonia, 34, 40-49 (2015-08-05)
Four morphologically similar specimens of an unidentified perithecial ascomycete were collected on decaying wood submerged in fresh water. Phylogenetic analysis of DNA sequences from protein-coding and ribosomal nuclear loci supports the placement of the unidentified fungus together with Achroceratosphaeria in
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