C4116

Cyclopamin

≥98% (HPLC), solid, Hedgehog signaling pathway inhibitor

• Synonym(e): 11-Deoxojervin
• Empirische Formel (Hill-System): C₂₇H₄₁NO₂ · xH₂O
• CAS-Nummer: 1217465-07-0
• Molekulargewicht: 411.62 (anhydrous basis)
• UNSPSC-Code: 12352116
• PubChem Substanz-ID: 24724439
• NACRES: NA.77

Eigenschaften

• product name: Cyclopamin, ≥98% (HPLC)
• Assay: ≥98% (HPLC)
• Form: solid
• Farbe: white
• Löslichkeit: DMSO: soluble ≥5 mg/mL; H₂O: insoluble
• Lagertemp.: 2-8°C
• SMILES String: O.C[C@@H]1CN[C@H]2[C@@H](C)[C@@]3(CC[C@H]4[C@@H]5CC=C6C[C@@H](O)CC[C@]6(C)[C@H]5CC4=C3C)O[C@@H]2C1
• InChI: 1S/C27H41NO2.H2O/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2;/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3;1H2/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-;/m0./s1
• InChIKey: KDAGJRDPNXDDSB-HBYCUIHISA-N
• Angaben zum Gen: human ... EBP(10682)

Beschreibung

Allgemeine Beschreibung

Cyclopamine is a steroidal alkaloid, extracted from Veratrum californicum. It prevents tumor cell growth and invasiveness in vitro and in vivo.

Anwendung

Cyclopamine hydrate has been used:

• as a sonic hedgehog (Shh) inhibitor in various experiments
• to explore the effects of stress stimulation on the proliferation and differentiation of fibrochondrocytes
• to study its influence on ocular vessel patterning

Biochem./physiol. Wirkung

Cyclopamine is a Hedgehog signaling pathway inhibitor; inhibits the growth of medulloblastoma cells.

Leistungsmerkmale und Vorteile

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)