C2917

Corticotropin Releasing Factor Antagonist

≥97% (HPLC)

• Synonym(e): α-Helical CRF (9-41), α-Helical corticotropin releasing factor fragment (9-41)
• Empirische Formel (Hill-System): C₁₆₆H₂₇₄N₄₆O₅₃S₂
• CAS-Nummer: 99658-03-4
• Molekulargewicht: 3826.36
• MDL-Nummer: MFCD00081543
• UNSPSC-Code: 12352200
• NACRES: NA.32

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥97% (HPLC)
• Form: powder
• Lagertemp.: −20°C
• Angaben zum Gen: human ... CRH(1392) ; mouse ... CRH(12918) ; rat ... CRH(81648)

Beschreibung

Amino Acid Sequence

Asp-Leu-Thr-Phe-His-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Ala-Glu-Gln-Ala-Leu-Asn-Arg-Leu-Leu-Glu-Ala-NH2

Biochem./physiol. Wirkung

The corticotropin releasing factor (CRF) antagonist α-helical CRF [9-41] exhibits 10-fold higher affinity for rat CRF_2α receptors over human CRF_2α receptors. It has been used to elucidate the role of CRF in various physiological systems. In colonic epithelium, it abolishes CRF-induced changes in ion secretion, and significantly inhibits CRF-stimulated conductance. It antagonizes the CRF-induced proinflammatory degranulation of perivascular mast cells that are activated in response to acute psychological stress and CRF secretion.

Sonstige Hinweise

Lyophilized from 0.1% TFA in H2O

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)