C2743

Cytochalasin B aus Drechslera dematioidea

Ready Made Solution, 10 mg/mL in DMSO

• Synonym(e): Phomin
• Empirische Formel (Hill-System): C₂₉H₃₇NO₅
• CAS-Nummer: 14930-96-2
• Molekulargewicht: 479.61
• Beilstein: 1096207
• MDL-Nummer: MFCD00077704
• UNSPSC-Code: 51102829
• PubChem Substanz-ID: 329774749
• NACRES: NA.85

Eigenschaften

• Qualitätsniveau: 200
• Form: solution
• Konzentration: 10 mg/mL in DMSO
• Wirkungsspektrum von Antibiotika: fungi
• Wirkungsweise: cell membrane | interferes
• Lagertemp.: −20°C
• SMILES String: C[C@@H]1CCC[C@@H](O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O
• InChI: 1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
• InChIKey: GBOGMAARMMDZGR-TYHYBEHESA-N

Beschreibung

Anwendung

Cytochalasin B from Drechslera dematioidea has been used:

• to block cytokinesis, to obtain binucleated cells
• as a specific glucose transporter inhibitor
• to inhibit glucose transport by class I and III GLUTs to determine the 50% inhibitory concentration (IC50) in HCMV-infected and mock-infected cells

Cytochalasin B is used to inhibit sugar transport in fibroblasts , decrease cytoskeletal actin and myosin in rabbit neutrophils , and to stimulate B lymphocytes .

Biochem./physiol. Wirkung

Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.

Cytochalasin B can prevent cytoplasmic division without affecting nuclear division.

Gehört zu einer Gruppe von Stoffwechselprodukten aus Pilzen, die eine Vielzahl zellulärer Bewegungen stören. Geeignetes Hilfsmittel für die Charakterisierung von einigen der Polymerisierungseigenschaften von Aktin und in Studien zur Zytokinese. Sonde für die beiden Hexose-Transportsysteme in L6-Myoblasten der Ratte.

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H302,H330
• P-Sätze: P260 - P264 - P270 - P271 - P301 + P312 - P304 + P340 + P310
• Gefahreneinstufungen: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 2
• Flammpunkt (°F): 185.0 °F - closed cup - Solvent
• Flammpunkt (°C): 85 °C - closed cup - Solvent
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter