C1743

Monoclonal Anti-Cul7 in Maus hergestellte Antikörper

clone Ab38, purified from hybridoma cell culture

• Synonym(e): Anti-Cullin 7, Anti-KIAA007
• MDL-Nummer: MFCD09265422
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: Ab38, monoclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~180 kDa
• Speziesreaktivität: human, mouse
• Konzentration: ~2 mg/mL
• Methode(n): immunoprecipitation (IP): suitable; western blot: 0.5-1 μg/mL using 3T3 total cel extract
• Isotyp: IgG2b
• UniProt-Hinterlegungsnummer: Q14999
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... CUL7(9820) ; mouse ... Cul7(66515)

Beschreibung

Allgemeine Beschreibung

Monoclonal Anti-Cul7 (mouse IgG2b isotype) is derived from the hybridoma Ab38 produced by the fusion of mouse myeloma cells (P3X63Ag8.653) and splenocytes from BALB/c mice immunized with mouse Cul7. CUL7 is expressed in all tissues and cell lines except testis and small intestine.

Immunogen

mouse Cul7.

Anwendung

Monoclonal Anti-Cul7 antibody produced in mouse is suitable for immunoprecipitation and western blotting at a concentration of 0.5-1μg/mL using 3T3 total cel extract.

Biochem./physiol. Wirkung

CUL7 functions to promote cell growth through and antagonizes the function of p53.

Cullin-7 (cul7) is a protein encoded by the CUL7 gene in humans. It is also referred as 3M1, KIAA0076 and dJ20C7.5. Mutation in CUL7 gene is majorly responsible for 3M syndrome (is a rare autosomal recessive disorder). CUL7 acts as a novel gene potentially involved in liver carcinogenesis associated with metabolic syndrome (MS) and its amplification may influence cell proliferation.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)