C1335

S-(−)-Carbidopa

≥98% (TLC), powder

• Synonym(e): (S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid, S-(−)-α-Hydrazino-3,4-dihydroxy-2-methylbenzenepropanoic acid
• Empirische Formel (Hill-System): C₁₀H₁₄N₂O₄
• CAS-Nummer: 28860-95-9
• Molekulargewicht: 226.23
• EG-Nummer: 249-271-9
• MDL-Nummer: MFCD00069231
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 24892402
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥98% (TLC)
• Form: powder
• Löslichkeit: methanol and 1 drop HCl: 4.90-5.10 mg/mL, clear, colorless to faintly yellow
• Lagertemp.: −20°C
• SMILES String: CC(Cc1ccc(O)c(O)c1)(NN)C(O)=O
• InChI: 1S/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)/t10-/m0/s1
• InChIKey: TZFNLOMSOLWIDK-JTQLQIEISA-N
• Angaben zum Gen: human ... DDC(1644)

Beschreibung

Allgemeine Beschreibung

Carbidopa is used for treating restless legs (RL) syndrome and periodic leg movements in sleep (PLMS). Carbidopa along with levodopa is used to treat Parkinson′s disease.

Biochem./physiol. Wirkung

Peripheral inhibitor of L-aromatic amino acid decarboxylase.

Peripheral inhibitor of L-aromatic amino acid decarboxylase. When co-administered with L-DOPA, it prevents extra-CNS conversion to dopamine, thereby increasing CNS concentrations of effective compounds. Selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells by increasing H₂O₂ in these cell lines, which are sensitive to reactive oxygen species.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)