C001

Acetylethylcholine mustard hydrochloride

>97% (GC), powder

• Synonym(e): Acetyl AF-64
• Empirische Formel (Hill-System): C₈H₁₆ClNO₂ · HCl
• CAS-Nummer: 103994-00-9
• Molekulargewicht: 230.13
• MDL-Nummer: MFCD00055153
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329774756
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: >97% (GC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white
• mp (Schmelzpunkt): 78-81 °C
• Löslichkeit: H₂O: >5 mg/mL; ethanol: soluble; methanol: soluble
• Lagertemp.: −20°C
• SMILES String: Cl[H].CCN(CCCl)CCOC(C)=O
• InChI: 1S/C8H16ClNO2.ClH/c1-3-10(5-4-9)6-7-12-8(2)11;/h3-7H2,1-2H3;1H
• InChIKey: CHWPASAPXMNLKO-UHFFFAOYSA-N

Beschreibung

Anwendung

Acetylethylcholine mustard hydrochloride has been used as a precursor in ethylcholine aziridinium (AF64A) preparation. It has also been used in the pharmacokinetic study to investigate its role in neuromuscular junction (NMJ) signal transmission and function.

Biochem./physiol. Wirkung

Acetylethylcholine mustard hydrochloride can reduce the contraction frequency of the myotubes by inhibiting the synthesis of acetylethylcholine (Ach) with the half-maximal inhibitory concentration (IC50) of 1.22 mM.

Acetylethylcholine mustard is a precursor for ethylcholine mustard aziridinium ion (AF-64A); irreversible ligand for the high affinity choline transport system; specific presynaptic long action cholinotoxin; inhibitor of choline acetyl-transferase.

Vorsicht

Extremely hygroscopic.

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H300 + H310 + H330,H315,H319,H335,H370
• P-Sätze: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 1 - STOT SE 3
• Zielorgane: Nervous system, Respiratory system
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): 204.8 °F - closed cup
• Flammpunkt (°C): 96 °C - closed cup