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Merck

A254

Sigma-Aldrich

AIDA

solid

Synonym(e):

1-Amino-2,3-dihydro-1H-indene-1,5-dicarboxylic acid, 1-Aminoindan-1, 5-dicarboxylic acid, UPF 523

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About This Item

Empirische Formel (Hill-System):
C11H11NO4
CAS-Nummer:
Molekulargewicht:
221.21
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.32

Form

solid

Qualitätsniveau

Farbe

white

Löslichkeit

DMSO: 2 mg/mL

SMILES String

NC1(CCc2cc(ccc12)C(O)=O)C(O)=O

InChI

1S/C11H11NO4/c12-11(10(15)16)4-3-6-5-7(9(13)14)1-2-8(6)11/h1-2,5H,3-4,12H2,(H,13,14)(H,15,16)

InChIKey

LSTPKMWNRWCNLS-UHFFFAOYSA-N

Angaben zum Gen

human ... GRM1(2911)
rat ... Grm1(24414)

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Biochem./physiol. Wirkung

Selective mGluR1 metabotropic glutamate receptor antagonist.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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F Moroni et al.
The Journal of pharmacology and experimental therapeutics, 281(2), 721-729 (1997-05-01)
We examined the pharmacological profile of 1-aminoindan-1,5-dicarboxylic acid (AIDA), a rigid (carboxyphenyl)glycine derivative acting on metabotropic glutamate receptors (mGluRs). In cells transfected with mGluR1a, AIDA competitively antagonized the stimulatory responses of glutamate and (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid [(1S,3R)-ACPD] on phosphoinositide hydrolysis (pA2
Andreas Schuster et al.
Journal of clinical medicine, 9(1) (2020-01-17)
Background: Right ventricular (RV) function is a known predictor of adverse events in heart failure and following acute myocardial infarction (AMI). While right atrial (RA) involvement is well characterized in pulmonary arterial hypertension, its relative contributions to adverse events following
Maria Joseph et al.
Molecular neurodegeneration, 12(1), 88-88 (2017-12-06)
The microtubule-associated protein Tau plays a role in neurodegeneration as well as neurogenesis. Previous work has shown that the expression of the pro-aggregant mutant Tau repeat domain causes strong aggregation and pronounced neuronal loss in the hippocampus whereas the anti-aggregant
Geetha Govind et al.
PloS one, 5(1), e8735-e8735 (2010-01-22)
Herbivore feeding elicits dramatic increases in defenses, most of which require jasmonate (JA) signaling, and against which specialist herbivores are thought to be better adapted than generalist herbivores. Unbiased transcriptional analyses of how neonate larvae cope with these induced plant
An H Do et al.
Journal of neuroengineering and rehabilitation, 10, 111-111 (2013-12-11)
Excessive reliance on wheelchairs in individuals with tetraplegia or paraplegia due to spinal cord injury (SCI) leads to many medical co-morbidities, such as cardiovascular disease, metabolic derangements, osteoporosis, and pressure ulcers. Treatment of these conditions contributes to the majority of

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