A1527
Adrenocorticotropic Hormone Fragment 7-38 human
≥97% (HPLC)
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Alle Fotos(1)
About This Item
Empirische Formel (Hill-System):
C167H257N47O46
CAS-Nummer:
Molekulargewicht:
3659.11
MDL-Nummer:
UNSPSC-Code:
51111800
NACRES:
NA.77
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Biologische Quelle
synthetic (organic)
Qualitätsniveau
Sterilität
non-sterile
Assay
≥97% (HPLC)
Form
powder
UniProt-Hinterlegungsnummer
Lagertemp.
−20°C
Angaben zum Gen
human ... POMC(5443)
Amino Acid Sequence
Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu
Anwendung
Adrenocorticotropic hormone fragment 7-38 human has been used as astandard in external calibration for mass spectrometry.
Biochem./physiol. Wirkung
Adrenocorticotropic hormone (ACTH) is a polypeptide hormone thatstimulates adrenocortical activity. It is produced by the prohormoneproopiomelanocortin (POMC), which is synthesized in the corticotroph andmelanotroph cells found in the intermediate and anterior lobe of the pituitarygland and the arcuate nucleus of the hypothalamus. ACTH is also synthesized inthe skin. It plays a role in controlling steroidogenesis in the adrenal glandand prevents reactive oxygen species (ROS)-induced cell toxicity. Higher levelsof ACTH lead to skin hyperpigmentation due to the hyperstimulation ofmelanocytes, characteristic of primary adrenal insufficiency (PAI). Deficiencyof ACTH synthesis, receptors, or signaling is associated with adrenalinsufficiency.
Sonstige Hinweise
ACTH fragment that is a potent inhibitor of ACTH-stimulated adenylate cyclase.
Lyophilized from 0.1% TFA in H2O
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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V L Clifton et al.
The Journal of clinical endocrinology and metabolism, 81(4), 1406-1410 (1996-04-01)
During human pregnancy, ACTH is produced by both the placenta and fetal pituitary. ACTH has been shown to cause vasodilatation in the adrenal cortex in vitro. In this context we have investigated the vasoactive effects of ACTH in the human
Adrenocorticotrophic hormone modulates Escherichia coli O157:H7 adherence to porcine colonic mucosa.
Kristin L Schreiber et al.
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L K Malendowicz et al.
The Journal of steroid biochemistry and molecular biology, 67(2), 149-152 (1999-01-07)
Corticotropin-inhibiting peptide (CIP), the 7-38 fragment of human ACTH(1-39), is known to act as an antagonist of ACTH receptors. Accordingly, CIP has been found to inhibit ACTH-stimulated glucocorticoid secretion of dispersed rat adrenocortical cells, without per se affecting the basal
L K Malendowicz et al.
The Journal of steroid biochemistry and molecular biology, 70(4-6), 185-188 (2000-01-06)
Orexins-A and B are two novel hypothalamic peptides, which, like leptin and neuropeptide-Y (NPY), are involved in the central regulation of feeding. Since leptin and NPY were found to modulate adrenal function, we have examined whether orexins are able to
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