A1164

Azaserin

Hybri-Max^™, γ-irradiated, 50x, lyophilized powder, BioXtra, suitable for hybridoma

• Synonym(e): O-Diazoacetyl-L-serin
• Empirische Formel (Hill-System): C₅H₇N₃O₄
• CAS-Nummer: 115-02-6
• Molekulargewicht: 173.13
• Beilstein: 1726602
• EG-Nummer: 204-061-6
• MDL-Nummer: MFCD00036802
• UNSPSC-Code: 12352207
• PubChem Substanz-ID: 24890511
• NACRES: NA.75

Eigenschaften

• Qualität: Hybri-Max^™
• Qualitätsniveau: 200
• Sterilität: γ-irradiated
• Produktlinie: BioXtra
• Form: lyophilized powder
• Methode(n): cell culture | hybridoma: suitable
• Verunreinigungen: endotoxin, tested
• Wirkungsspektrum von Antibiotika: fungi
• Wirkungsweise: enzyme | inhibits
• Lagertemp.: −20°C
• SMILES String: N[C@@H](COC(=O)C=[N+]=[N-])C(O)=O
• InChI: 1S/C5H7N3O4/c6-3(5(10)11)2-12-4(9)1-8-7/h1,3H,2,6H2,(H,10,11)/t3-/m0/s1
• InChIKey: MZZGOOYMKKIOOX-VKHMYHEASA-N

Beschreibung

Allgemeine Beschreibung

Chemical structure: amino acid derivatives

Anwendung

For use in hybridoma cell culture applications as a myeloma selection agent. Used to study inhibition of formylglycinamide ribonucleotide amidotransferase and PRPP amidotransferase.

Biochem./physiol. Wirkung

Azaserine is an antibiotic, generated by Streptomyces fragilis. It is considered as a potential mutation inducing agent. It is known to promote pancreatic cancer and induces adenoma and carcinoma in vivo and in vitro. Azaserine also stimulates kidney and liver tumors in rats.

Rekonstituierung

Reconstitute contents of vial with 10 mL sterile cell culture medium. Stock solution is sufficient to prepare 500 mL medium. Final working concentration: 5.7 μM azaserine.

Rechtliche Hinweise

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H301,H351
• P-Sätze: P201 - P301 + P310 + P330
• Gefahreneinstufungen: Acute Tox. 3 Oral - Carc. 2
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges