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44977

Sigma-Aldrich

DISBAC2(3), spannungssensitive Sonde

≥98% (HPLC)

Synonym(e):

5-[3-(1,3-Diethylhexahydro-4,6-dioxo-2-thioxo-5-pyrimidinyl)-2-propen-1-yliden]-1,3-diethyldihydro-2-thioxo-4,6(1H,5H)-pyrimidindion, Bis-(1,3-diethylthiobarbitursäure)-trimethinoxonol

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About This Item

Empirische Formel (Hill-System):
C19H24N4O4S2
CAS-Nummer:
47623-98-3
Molekulargewicht:
436.55
Beilstein:
1232950
EG-Nummer:
256-325-5
MDL-Nummer:
MFCD07437858
UNSPSC-Code:
12352108
PubChem Substanz-ID:
329756577
NACRES:
NA.32

Qualitätsniveau

100

Assay

≥98% (HPLC)

Fluoreszenz

λex 535 nm; λem 560 nm in DMSO

Eignung

complies for Infrared spectrum

Lagertemp.

−20°C

SMILES String

CCN1C(=O)C(\C=C\C=C2\C(=O)N(CC)C(=S)N(CC)C2=O)C(=O)N(CC)C1=S

InChI

1S/C19H24N4O4S2/c1-5-20-14(24)12(15(25)21(6-2)18(20)28)10-9-11-13-16(26)22(7-3)19(29)23(8-4)17(13)27/h9-12H,5-8H2,1-4H3/b10-9+

InChIKey

VJYNRXFXHKIGLT-MDZDMXLPSA-N

Anwendung

DISBAC2(3), Voltage Sensitive Probe is used for single-cell fluorescence imaging of transmembrane conductance and potential change.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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S Amoroso et al.
Biochimica et biophysica acta, 1239(1), 67-73 (1995-10-04)
In this study the effect of the A1 agonist 2-chloro-N6-cyclopentyladenosine (CCPA) on bis(1,3-diethylthiobarbituric acid)trimethine oxonol (bisoxonol)-monitored membrane potential in cerebrocortical nerve endings was evaluated. CCPA (30, 100 and 300 microM) caused a dose-dependent decrease of high K(+)- and veratridine-induced membrane
S Bouhdid et al.
Journal of applied microbiology, 109(4), 1139-1149 (2010-05-12)
To study cellular damage induced by Cinnamomum verum essential oil in Pseudomonas aeruginosa ATCC 27853 and Staphylococcus aureus ATCC 29213. The effect of cinnamon bark essential oil on these two strains was evaluated by plate counts, potassium leakage, flow cytometry
N Minami et al.
Journal of neural transmission. General section, 97(1), 65-72 (1994-01-01)
Effects of cyclic AMP on membrane potentials were examined by measuring the changes of bis-oxonol fluorescence in bovine adrenal medullary chromaffin cells. 8-Bromo cyclic AMP (8Br-cAMP) or forskolin caused a gradual and long lasting increase of the fluorescence intensity. The
M K Tanner et al.
Cytometry, 14(1), 59-69 (1993-01-01)
Immunosuppression by the fungal metabolite cyclosporin A (CsA) is characterized by functional inhibition, rather than destruction of cells. Because activation of immune cells involves intracellular signalling events associated with modulations of cell transmembrane potential (TMP), we tested the ability of
Mikiyo Yamaguchi et al.
Anesthesia and analgesia, 100(2), 419-426 (2005-01-28)
The membrane potential of endothelial cells is an important determinant of endothelial functions, including regulation of vascular tone. We investigated whether adenosine triphosphate-sensitive potassium (K(ATP)) channels were involved in the response of membrane potential to hyperosmolality in cultured human aorta
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